谷氨酸脱氢酶的基本特性及其与疾病的相关研究进展  

Characteristics of glutamate dehydrogenase and its effect on diseases

作　　者：徐晓光[1] 朱静[1,2] 师俊玲[1] 邵东燕[1] 黄庆生[1] 

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术重点实验室,西安710072 [2]信阳农林学院食品学院,信阳464000

出　　处：《生命科学》2016年第11期1314-1320,共7页Chinese Bulletin of Life Sciences

基　　金：国家科技支撑计划(2015BAD16B02);国家自然科学基金项目(31201408);陕西省自然科学基金项目(2015JQ3083);西安市科技计划项目(CXY1434)

摘　　要：谷氨酸脱氢酶(GDH)存在于所有生物体中,在三羧酸循环、氨代谢调控、能量产生和信号转导中起着重要作用。关于GDH的研究报道已有很多,涉及到植物氮代谢、微生物生理、动物神经调节以及其本身的生产应用,但有关其与人类疾病间关系的文献综述尚未见报道。在对GDH基本特性进行归纳和总结的基础上,对其与高胰岛素-高血氨综合征、帕金森病,以及不同癌症间关系等方面的最新研究进展进行了综述,以期为相关研究提供参考。Glutamate dehydrogenase （GDH） exists in all living organisms and plays an important role in the Krebs cycle, ammonia metabolism regulation, energy production and cell signaling. Many researches have been carried out on GDH in recent years, including plant nitrogen metabolism, microbial physiology, animal neural regulation and its application in industrial production. However, there is still lack of comprehensive review on the relationship between this enzyme and human diseases. Therefore, this article reviewed the new development in the characteristics of GDH, and its relationship with some diseases, especially with hyperinsulinism/hyperammonemia syndrome, Parkinson＇s disease and cancers to provide useful information for relative researches in the future.

关 键 词：谷氨酸脱氢酶 特性 高胰岛素.高血氨综合征 帕金森病 肿瘤 

分 类 号：Q554.4[生物学—生物化学]