两种质量浓度丝裂霉素C应用于青光眼手术中的效果比较  

Comparison of the effect of mitomycin C in different concentrations in glaucoma operation

作　　者：苗晓晴[1] 黄祖烽 陈玄之[1] 陈荟郦[1] 

机构地区：[1]广东省湛江中心人民医院眼科,广东湛江524037

出　　处：《广东医学院学报》2016年第4期419-421,共3页Journal of Guangdong Medical College

摘　　要：目的比较小梁切除术中使用两种不同质量浓度丝裂霉素C(mitomycin C,MMC)治疗青光眼的临床疗效。方法青光眼小梁切除术53例(66眼)随机分为低质量浓度组(27例33眼)和高质量浓度组(26例33眼),分别使用质量浓度为0.2、0.4 g/L的MMC治疗。术后随访半年,观察患者的滤过泡情况、眼压变化和并发症情况。结果低浓度组、高浓度组术后分别有4例(5眼)、3例(5眼)未能坚持随访。两组患者术后1周的眼压与术前比较差异无统计学意义(P>0.05),术后6个月高质量浓度组的眼压低于同期的低质量浓度组(P<0.01)。两组术后滤过泡及并发症发生率的差异均无统计学意义(均P>0.05)。结论使用0.2 g/L或0.4 g/L质量浓度MMC联合小梁切除术治疗青光眼均可有效降低眼压,但高质量浓度组控制眼压远期效果更为理想。Objective To observe the clinical curative effect of mitomycin C （MMC） in two different concentrations in trabeculectomy for the treatment of glaucoma. Methods 53 cases （66 eyes） treated with glaucoma trabeculectomy in our hospital were randomly divided into Low Concentration Group （33 eyes of 27 cases） and High Concentration Group （33 eyes of 26 cases）, receiving treatment with 0.2 and 0.4 g/L MMC respectively. All the patients were followed up for halfa year, and the filtering bleb, intraocular pressure and complications of the patients were observed. Results There were 4 cases （5 eyes） and 3 cases （5 eyes） in Low Concentration Group and High Concentration Group failing to be follow-up after operation. There was no significant difference in the mean lOP of both groups before operation and 1 week after operation （P〉0.05）. Six months after operation, High Concentration Group had an IOP lower than Low Concentration Group at the same period （P〈0.01）, There was no difference in filtering bleb and the incidence of complications between the two groups （P〉0.05）. Conclusion The use of 0.2 g/L or 0.4 g/L MMC combined with trabeculectomy in the treatment of glaucoma can effectively reduce the intraocular pressure, but High Concentration Group has a more ideal long-term effect in controlling intraocular pressure.

关 键 词：青光眼 丝裂霉素C 小梁切除术 眼压 滤过泡 

分 类 号：R775.05[医药卫生—眼科]