儿童神经母细胞瘤复发病例回顾性分析  

Retrospective analysis of clinical features in children with relapsed neuroblastoma

作　　者：管娜[1] 孙凤华[2] 张语桐[1] 王立哲 钟晓丹[1] 常健[1] 

机构地区：[1]吉林大学第一医院儿童肿瘤科,长春130021 [2]吉林省蛟河市人民医院儿科,蛟河132500

出　　处：《中国小儿血液与肿瘤杂志》2016年第4期207-210,共4页Journal of China Pediatric Blood and Cancer

摘　　要：目的总结分析儿童神经母细胞瘤(NB)复发病例的特点,探讨治疗策略改进的可能性。方法总结2008年10月-2010年5月我科诊治后随诊观察的23例高危NB患儿复发情况,并归纳其特点。结果 23例NB患儿治疗后2年随诊中7例复发,其中临床分期Ⅳ期5例,Ⅲ期2例;中枢神经系统(CNS)复发3例,其中同时伴骨髓复发2例,原发灶复发1例;CNS复发早期症状包括:晕车、恶心、腹部不适、乏力和下肢无力等;香草基扁桃酸(VMA)和高香草酸(HVA)水平在CNS复发病例中升高不明显。结论 CNS是常见的NB复发部位之一,早期临床症状、体征不典型;VMA和HVA对CNS复发缺乏特异性。Objective To summarize and analyze the features of children with relapsed neuroblastoma（NB）,and explore the possible strategies for improvement of NB.Methods Summarize the relapse status in 23 children with high-risk NB cases treated in our hospital,and analyze their relapse features.Results Among 23 cases with NB,7 cases relapsed,5 cases in stage Ⅳ,and 2 cases in stageⅢ.Three cases were identified with central nervous system relapse,2 of them accompanying with bone marrow involvement and 1 case with primary site relapse.The early symptoms included carsickness,nausea,abdominal discomfort,lack of power on lower limbs and fatigue.The serum levels of vanillylmandelic acid（VMA） and Homovanilic acid（HVA） didn＇t significantly increase at relapses.Conclusions Central nervous system was one of the common places for NB relapse,and the early symptoms and signs were not typical.VMA and HVA were not the specific indications for NB relapse.

关 键 词：神经母细胞瘤 复发 中枢神经系统 

分 类 号：R739.4[医药卫生—肿瘤]