进展期胃癌术中精准腹腔热灌注治疗的效果评价  

Evaluation of Therapeutic Effect of Intraperitoneal Perfusion in Advanced Gastric Cancer

作　　者：贺阳[1] 宋展[2] 

机构地区：[1]新乡医学院研究生处,河南新乡453003 [2]南阳市中心医院普通外科,河南南阳473000

出　　处：《中国继续医学教育》2016年第30期125-127,共3页China Continuing Medical Education

摘　　要：目的探讨进展期胃癌术中精准腹腔热灌注治疗的临床效果。方法对我院2012年3月-2013年3月接受D2根治性胃癌切除术的进展期胃癌患者80例的临床资料进行回顾性分析。术中行精准腹腔热灌注治疗者40例（研究组）,术中仅行常规腹腔冲洗者40例（对照组）,两组均于术后3-4周按m FOLFOX6方案行全身静脉化疗,对比两组术前、术后1个月肿瘤标志物CEA与CA19-9变化,术后3年腹腔局部复发率及生存率。结果术后1个月CEA与CA19-9均有下降,但研究组下降更显著（P〈0.05）;研究组3年腹腔局部复发率低于对照组,3年生存率高于对照组,差异均有统计学意义（P〈0.05）。结论进展期胃癌术中精准腹腔热灌注治疗能显著降低患者外周血CEA、CA19-9的水平,降低3年腹腔局部复发率,提高3年生存率。Objective To study the advanced gastric cancer clinical effect of intraoperative precise celiac hot perfusion chemotherapy. Methods Clinical data of 80 patients with advanced gastric cancer who underwent D2 radical gastrectomy for gastric cancer were retrospectively analyzed in our hospital from March 2012 to March 2013. 40 cases of intraoperative accurate peritoneal perfusion treatment（study group）, 40 patients who underwent routine peritoneal lavage（control group）, two groups in the postoperative 3 to 4 weeks plan according to m FOLFOX6 for intravenous chemotherapy, compared two groups before and 1 months after surgery and tumor marker CEA the change of CA19-9, 3 years after surgery were local recurrence rate and survival rate. Results 1 months after the operation of CEA and CA19-9 were decreased, but the study group significantly decreased（P〈0.05）, study group 3 years local recurrence of abdominal cavity was lower than the control group, the 3 year survival rate was higher than the control group, the differences were statistically significant（P〈0.05）. Conclusion In advanced gastric cancer surgery, precise intraperitoneal perfusion can reduce the content of CEA and CA19-9 in peripheral blood, and decrease the local recurrence rate in 3 years, and increase the survival rate of 3 years.

关 键 词：胃肿瘤 化疗疗法 肿瘤 局部灌注 

分 类 号：R735[医药卫生—肿瘤]