双歧杆菌联合柳氮磺胺嘧啶对溃疡性结肠炎患者血清炎症因子、免疫功能的影响  

Effect of bifidobacteria combined with sulfasalazine on serum inflammatory factors and immune functions in patients with ulcerative colitis

作　　者：李志明 李信健 谭仲华 谢丽媚 邓新芝 

机构地区：[1]广东省肇庆市端州区人民医院内三科,广东肇庆526040 [2]广东省肇庆市端州区人民医院内镜中心,广东肇庆526040

出　　处：《海南医学院学报》2016年第21期2541-2543,2547,共4页Journal of Hainan Medical University

基　　金：广东省卫生厅基金资助项目(A2013879)~~

摘　　要：目的:观察双歧杆菌联合柳氮磺胺嘧啶对溃疡性结肠炎患者血清炎症因子、免疫功能的影响。方法:将126例UC患者随机分为观察组(66例)和对照组(60例)。对照组给予柳氮磺胺吡啶,观察组在对照组的基础上给予双歧杆菌活菌。治疗2月,观察两组血清炎症因子(TNF-α、IL-6、IL-8、IL-10)及免疫功能(T淋巴细胞亚群CD3、CD4、CD8、CD4/CD8及免疫球蛋白IgG、IgA、IgM)的差异。结果:(1)血清炎症因子比较治疗后,两组TNF-α、IL-6、IL-8下降而IL-10上升(P<0.05),且观察组变化幅度大于对照组,同期比较差异有统计学意义(P<0.05);(2)T淋巴细胞亚群比较治疗后,两组CD3、CD4、CD4/CD8下降而CD8上升(P>0.05),且观察组变化幅度大于对照组,同期比较差异有统计学意义(P<0.05);(3)免疫球蛋白比较治疗后,两组IgG、IgA及IgM均明显下降(P<0.05),且观察组变化幅度大于对照组,同期比较差异有统计学意义(P<0.05)。结论:双歧杆菌联合柳氮磺胺吡啶治疗UC时抑制炎症反应、调节免疫功能作用强于单用柳氮磺胺吡啶。Objective：To observe the effect of bifidobacteria combined with sulfasalazine on serum inflammatory factors and immune functions in patients with ulcerative colitis （UC）.Methods：A total of 126 UC patients were selected and randomly divided into observation group （66 cases）and control group （60 cases）.The control group was given sulfasalazine,and the ob-servation group was given bifidobacteria based on the control group.After treatment for 2 months,the differences of serum in-flammatory factors （TNF-α,IL-6,IL-8,IL-10）and immune function （T lymphocyte subsets CD3,CD4,CD8,CD4/CD8 and immunoglobulins IgG,IgA,IgM）between the two groups were observed.Results：After treatment,TNF-α,IL-6,IL-8 in the two groups significantly decreased but IL-10 significantly increased （P 〈0.05）,rangeabilities of the above indexes in observa-tion group were significantly greater than that in control group （P 〈0.05）.CD3,CD4,CD4/CD8 in the two groups significantly decreased but CD8 significantly increased （P 〈0.05）,and rangeabilities of the above indexes in observation group were signifi-cantly greater than that in control group （P 〈0.05）.IgG,IgA and IgM in the two groups significantly decreased （P 〈0.05）,＆nbsp;and rangeabilities of the above indexes in observation group were significantly greater than that in control group.Conclusions：Compared with alone use of sulfasalazine,bifidobacteria combined with sulfasalazine is more efficient in inhibiting inflammatory reactions and regulating immune functions for the treatment of UC.

关 键 词：溃疡性结肠炎 双歧杆菌 炎症因子 免疫功能 

分 类 号：R574.62[医药卫生—消化系统]