激素替代治疗对宫颈鳞状细胞癌患者术后性激素及肿瘤标志物的影响  

Effect of hormone replacement therapy on sex hormones and tumor markers in cervical squamous cell carcinoma postoperative patients

作　　者：丁红岩[1] 徐洪阁[1] 高金瑜[1] 宋禹辰 

机构地区：[1]江苏省淮安市第一人民医院妇科,江苏淮安223300

出　　处：《海南医学院学报》2016年第23期2858-2861,共4页Journal of Hainan Medical University

基　　金：江苏省卫生厅重点学科省内开放课题(VH201599)~~

摘　　要：目的：探讨激素替代治疗对宫颈鳞状细胞癌患者术后性激素及肿瘤标志物的影响。方法：选择2012年1月-2014年12月江苏省淮安市第一人民医院收治的100例宫颈鳞状细胞癌患者为研究对象,其中观察组（58例）患者愿意接受激素替代治疗,对照组（42例）不愿意接受激素替代治疗,进行常规治疗。在治疗前及治疗后,分别检测两组患者血清中性激素及肿瘤标志物水平。结果：治疗前,两组患者血清E2、FSH、LH水平比较无明显差异（均P〉0.05）;治疗后,观察组中血清E2水平与治疗前相比明显升高（P〈0.05）,且与治疗后的对照组中血清E2水平相比也明显升高（P〈0.05）,血清FSH和LH水平较治疗前明显降低（均P〈0.05）,且明显低于治疗后对照组中血清FSH和LH水平（均P〈0.05）,差异均有统计学意义;对照组治疗后血清E_2水平稍有下降,FSH和LH水平稍有升高,但均无统计学差异（均P〉0.05）,不具有统计学意义。两组患者治疗前血清鳞状细胞癌抗原（SCC-Ag）、基质属蛋白酶2（MMP-2）、基质属蛋白酶9（MMP-9）和血管内皮生长因子C（VEGF-C）水平比较均无明显差异（均P〉0.05）;治疗后,两组患者血清SCC-Ag、VEGF-C、MMP-2和MMP-9水平比较仍无明显差异（均P〉0.05）,差异不具有统计学意义。结论：宫颈鳞状细胞癌患者使用激素替代治疗后能明显改善由低雌激素引起的不良症状,提高患者生活质量,同时短期内不会对患者的预后造成影响。Objective：To investigate the effect of hormone replacement therapy on sex hormones and tumor markers in cervical squamous cell carcinoma postoperative patients.Methods：A total of 100 cases of cervical squamous cell carcinoma patients treated in our hospital were selected as research objects,and the observation group（58cases）were willing to receive hormone replacement therapy,while the control group（42cases）were not willing to receive hormone replacement therapy,with routine treatment.Before and after treatment,the serum levels of neutral hormone and tumor markers were detected in two groups of patients.Results：Before treatment,there were no significant differences in serum E2,FSH and LH levels between the two groups（all P〉0.05）;after treatment,in the observation group compared with before treatment,the level ofserum E2 increased significantly（P〈0.05）,and was significantly higher than the control group after treatment（P〈0.05）,compared with before treatment,serum FSH and LH levels decreased significantly（P〈0.05）,and were significantly lower than those of the control group after treatment（P〈0.05）,the differences were statistically significant;in the control group after treatment,the serum E2 level was slightly decreased,FSH and LH levels were slightly elevated,but there was no statistical difference（all P〈0.05）,which was not statistically significant.Berore and after treatment,the levels of serum SCC-Ag,VEGF-C,MMP-2and MMP-9showed no significant differences between the two groups（all P〈0.05）,the difference were not statistically significant.Conclusion：The use of hormone replacement therapy in cervical squamous cell carcinoma patients can significantly improve the adverse symptoms caused by low estrogen,improve the quality of life of patients,and not affect the prognosis of patients in the short term.

关 键 词：激素替代治疗 宫颈鳞状细胞癌 性激素 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]