氯胺酮和速眠新Ⅱ复合麻药剂量对巴马小型猪的麻醉效果及影响  

The Anesthesia Effects of Ketamine and Sumianxin Ⅱ on Bama MiniPig

作　　者：焦昆[1] 朱力鸣[1] 卢静[1] 

机构地区：[1]首都医科大学实验动物部,北京100069

出　　处：《实验动物科学》2016年第5期57-60,共4页Laboratory Animal Science

基　　金：首都医科大学校长基金的资助(No.1140170256)

摘　　要：目的研究氯胺酮和速眠新Ⅱ复合麻醉方法用于巴马小型猪实验的麻醉效果,初步观察复合麻药对动物机能指标的影响。方法使用氯胺酮和速眠新Ⅱ按2∶1.5(m L)的体积制成混合麻醉剂,在0.3—0.5 m L/kg的剂量范围内,给予动物一定剂量的麻药进行麻醉,记录麻药剂量、麻醉效果和生理指标。结果随着麻醉剂量的增加,麻药起效时间、肌松时间和眼睑反射消失时间均降低;动物心率和呼吸频率增加,对血压影响不大。结论 0.3—0.4m L/kg可以作为安全剂量用于小型猪的麻醉,不但起到良好的麻醉效果,对生理指标影响也不大。Objective To study the anesthesia effect of Ketamine and Sumianxin Ⅱ on minipigs,to investigate the effects of two kinds of anesthetic on physiology of animal. Method Ketamine and Sumianxin Ⅱ were mixed together,the volume（ between 0. 3 to 0. 5 m L/kg） of the mixture was used for anesthesia,then the anesthetic effect and physiology index were recorded. Result With the increasing of anesthesia dose,the length of anesthesia effect-act,muscle relaxant and eyelid reflex disappearing were decreasing. The heart rate and respiratory rate of animals in high dose（ 0. 4—0. 5 m L/kg） group higher than low dose（ 0. 3—0. 4 m L/kg） group. The mean arterial pressure and the oxygen saturation were similar between two groups. Conclusion 0. 3—0. 4 m L/kg could be used safely for anesthesia on minipig,this dose could offered not only good anesthesia effect but also little impact on physiology indexes.

关 键 词：巴马小型猪 氯胺酮 速眠新Ⅱ 麻醉 

分 类 号：R-332[医药卫生]