恶性肿瘤的光学分子影像手术导航  

Optical molecular imaging guided surgical navigation for cancers

作　　者：贺丽芳[1] 黄文河[1] 张国君[1,2] 

机构地区：[1]汕头大学医学院附属肿瘤医院乳腺中心,广东省汕头市515041 [2]汕头大学医学院长江学者实验室

出　　处：《中国肿瘤临床》2016年第21期927-931,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金重大国际(地区)合作研究项目(编号:81320108015);国家自然科学基金(编号:31271068)资助;广东省实验室体系建设专项资金(编号:2060299)~~

摘　　要：光学分子影像是利用生物体自发荧光和荧光素酶的探针对分子和分子作用途径监测的一种无创技术,具有操作简单、无创伤、即时性、高敏感性、成像价格低的优点,被越来越多地应用于生物学、医学等生命科学领域。常用的光学分子影像研究的荧光探针主要有内源性的荧光素酶、外源性的绿色荧光蛋白及近红外荧光染料等。外科手术是恶性肿瘤的主要治疗方法之一,如何在手术中实时动态检测前哨淋巴结、确定肿瘤浸润和转移范围、判定肿瘤切缘是否安全及保护神经等功能是肿瘤外科医生面临的临床挑战。光学分子影像手术导航正在逐步应用到以上领域,期待可以解决以上问题,最终可以使恶性肿瘤被精准切除。本文就目前国内外光学分子影像技术在恶性肿瘤手术导航领域的应用进行综述。Optical molecular imaging is a non-invasive technology that utilizes biological autofluorescence and fuciferase probes to monitor molecules and molecular pathways. In recent years, the simple, non-invasive, real-time, highly sensitive, and low-cost applica- tions of optical molecular imaging have been extensively utilized in the medical and life science fields. Optical molecular imaging re- search studies commonly use fluorescent probes that contain luciferase, green fluorescent protein, and indocyanine green, a near-in- frared fluorescent dye. Given that surgery is a main therapeutic strategy for solid tumors, imaging-guided surgery provides new in- sights on the precise resection of cancerous tissues. In particular, considerable attention is focused on developing dynamic and real- time sentinel lymph node （SLN） navigation to determine the extent of tumor resection and secure free tumor margins. In this article, we review the applications of intraoperative optical molecular imaging as a surgical navigation technology. These applications include, but are not limited to, accurately identifying SLNs, detecting tumor margins, and determining the extent of tumor resection.

关 键 词：光学分子影像 恶性肿瘤 肿瘤切缘 手术导航 

分 类 号：R730.56[医药卫生—肿瘤]