西洋参滴丸制备工艺  

Preparation Technology of American Ginseng Dropping Pills

作　　者：燕继永 李爱云[2] 冯坤苗 张强[1] 崔耀天[1] 张盼盼[1] 韩春超[1] YAN Jiyong LI Aiyun FENG Kunmiao ZHANG Qiang CUI Yaotian ZHANG Panpan HAN Chunchao(College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China Department of Pharmacy, the Second Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan 250002, China)

机构地区：[1]山东中医药大学药学院,济南250355 [2]山东中医药大学第二附属医院药剂科,济南250002

出　　处：《医药导报》2016年第11期1249-1253,共5页Herald of Medicine

摘　　要：目的优选西洋参滴丸的最佳制备工艺。方法在单因素实验的基础上,以药物与基质的比例、滴制温度、冷凝液的温度为考察因素,以滴丸的成型率作为指标,响应面优化西洋参滴丸的制备工艺。结果西洋参滴丸的最佳制备工艺条件为:聚乙二醇4000和聚乙二醇6000(1∶1)为基质,药物与基质的比例为1∶6,液体石蜡为冷凝剂,滴制温度为90℃,冷凝温度为2℃。结论制备的滴丸硬度和圆整度较好,成型率高,符合滴丸的质量要求,可用于西洋参滴丸的制备。Objective To optimize the preparation technology of American ginseng dropping pills. Methods Based on preliminary experiments, the ratio of drugs/matrix, temperature of dripping, and condensing as inspective factors. Chosen dropping pills forming as optimizing index, optimized the preparation technology of American ginseng dropping pills by response surface methodology. ＇ Results The optimized preparation condition was as follows ： matrix PEG4000 to PEG6000 at 1 ： 1, drug to matrix at 1 ： 6, condensing agents used as liquid paraffin, dripping temperature at 90 ℃, and condensing temperature at 2 ℃, respectively. Conclusion The American ginseng dropping pills made by this method have better properties of hardness, roundness, and forming rate, and complies with the quality requirements.The process can be used for the preparation of American ginseng dropping pills.

关 键 词：西洋参滴丸 制备工艺 响应面优化法 

分 类 号：R286[医药卫生—中药学] TQ460.1[医药卫生—中医学]