靶向 EphB4受体分子探针的研究进展  

Advance of molecular imaging probes targeted for EphB4 receptor

作　　者：解清华 朱华[1] 刘菲[1] 韩雪迪 夏传琴[2] 杨志[1] Xie Qinghua Zhu Hua Liu Fei Han Xuedi Xia Chuanqin Yang Zhi(Department of Nuclear Medicine, Peking University Cancer Hospital ＆ Institute, Key Laboratory of Carcinogenesis and Translational Research, Beifing 100142, China College of Chemistry, Sichnan University, Chengdu 610041, Chin)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科恶性肿瘤发病机制及转化研究所教育部重点实验室,100142 [2]四川大学化学学院

出　　处：《国际肿瘤学杂志》2016年第11期841-844,共4页Journal of International Oncology

基　　金：国家自然科学基金（81371592、81401467、81571705、81501519）;北京市自然科学基金（7154188）

摘　　要：促红细胞生成素产生肝细胞受体（Eph）B 型受体4与肿瘤生长和肿瘤血管形成密切相关，并且在许多肿瘤中过量表达。EphB4靶向探针可提高肿瘤诊断的准确性和特异性。大量针对该靶点的分子探针已经被设计出来，有望为肿瘤的早期诊断和治疗提供新的方法。The erythropoietin-producing hepatocellular receptor （Eph）B4 receptor is closely associa-ted with tumor growth and angiogenesis,which is over-expressed in a wide variety of tumors.Molecular probes targeted for EphB4 receptor can improve the accuracy and specificity of tumor diagnosis.A lot of molecular probes targeted for EphB4 receptor have been designed,which are expected to provide new means for the early diagnosis and therapeutics of tumors.

关 键 词：受体 EphB4 肿瘤 核医学 分子探针 

分 类 号：R73-3[医药卫生—肿瘤]