放疗与肿瘤免疫  

Radiotherapy and tumor immunity

作　　者：许涛[1] 景红霞[1] Xu Tao Jing Hongxia(Department of Oncology, People＇s Hospital, Hubei University of Medicine, Shiyan 442000, Chin)

机构地区：[1]十堰湖北医药学院附属人民医院肿瘤中心超声科,442000

出　　处：《国际肿瘤学杂志》2016年第11期855-857,共3页Journal of International Oncology

基　　金：十堰市科学技术研究与开发项目（16Y46）

摘　　要：肿瘤微环境中的免疫细胞和细胞因子在抗肿瘤免疫中具有不同功能。放疗可通过放射生物效应杀伤肿瘤细胞，同时还能间接改变肿瘤免疫微环境，协同产生局部或远处抗肿瘤免疫效应。放疗联合免疫治疗的动物和临床试验证实其良好的应用前景，联合治疗时具体的放射治疗模式尚需进一步研究。Infiltrated immune cells and cytokines in the tumor microenvironment may play different functions that appear tightly related to clinical outcomes.Radiotherapy mainly kills tumor cells through radiobio-logical effect,meanwhile it can indirectly change tumor immunologic microenvironment,and has a local or dis-tant anti-tumor immunological effect cooperatively.Animal experiments and clinical trials of radiotherapy com-bined with immunotherapy display well applied prospects,but the mode of radiotherapy in combined treatment needs further research.

关 键 词：放射疗法 免疫 

分 类 号：R730.55[医药卫生—肿瘤]