HMG：心脏病发作的记忆储存在我们的基因中  

Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction

作　　者：Mathias Rask-Andersen David Martinsson Muhammad Ahsan Stefan Enroth Weronica E. Ek Ulf Gyllensten sa Johansson 

机构地区：[1]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden * To whom correspondence should be addressed at: Mathias Rask-Andersen, Department of Immunology, Genetics and Pathology, Uppsala University, BMC, Husargatan 3, Box 815, 751 08 Uppsala, Sweden. Tel: [phone] Email: [e-mail] Search for other works by this author on: Oxford Academic PubMed Google Scholar [2]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar [3]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar [4]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar [5]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar [6]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar [7]1 Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar

出　　处：《现代生物医学进展》2016年第31期I0004-I0004,共1页Progress in Modern Biomedicine

摘　　要：遗传因素和环境因素影响我们的心血管疾病风险。如今。在一项新的研究中，来自瑞典乌普萨拉大学的研究人员发现心脏病发作的记忆能够通过表观遗传变化储存在我们的基因中。相关研究结果在线发表在Human Molecular Genetics期刊上。Cardiovascular diseases (CVDs) are the leading causes of death worldwide and represent a substantial economic burden on public health care systems. Epigenetic markers have potential as diagnostic markers before clinical symptoms have emerged, and as prognostic markers to inform the choice of clinical intervention. In this study, we performed an epigenome-wide association study (EWAS) for CVDs, to identify disease-specific alterations in DNA methylation. CpG methylation in blood samples from the northern Sweden population health study (NSPHS) (n = 729) was assayed on the Illumina Infinium HumanMethylation450 BeadChip. Individuals with a history of a CVD were identified in the cohort. It included individuals with hypertension (N = 147), myocardial infarction (MI) (N = 48), stroke (N = 27), thrombosis (N = 22) and cardiac arrhythmia (N = 5). Differential DNA methylation was observed at 211 CpG-sites in individuals with a history of MI (q <0.05). These sites represent 196 genes, of which 42 have been described in the scientific literature to be related to cardiac function, cardiovascular disease, cardiogenesis and recovery after ischemic injury. We have shown that individuals with a history of MI have a deviating pattern of DNA methylation at many genomic loci of which a large fraction has previously been linked to CVD. Our results highlight genes that might be important in the pathogenesis of MI or in recovery. In addition, the sites pointed out in this study can serve as candidates for further evaluation as potential biomarkers for MI.

关 键 词：心脏病 基因 储存 记忆 HMG 心血管疾病 HUMAN 环境因素 

分 类 号：Q78[生物学—分子生物学]