丙泊酚对脑损伤术后患者血浆β-内啡肽、血清热休克蛋白70、血乳酸及血糖的影响  

The Effect of Propofol on the Stress Indicators after Brain Injury

作　　者：于航 王迪芬[2] 王小智 YU Hang WANG Difen WANG Xiaozhi(Department of Critical Care Medicine, Hainan Provincial Nongken General Hospital, Haikou 570311, Hainan, China Department of Critical Care Medicine, Gttizhou Medicine University, Guiyang 550000, Guizhou, China)

机构地区：[1]海南省农垦总医院重症医学科,海南海口570311 [2]贵州医科大学附院重症医学科,贵州贵阳550000

出　　处：《贵州医科大学学报》2016年第11期1311-1313,共3页Journal of Guizhou Medical University

基　　金：贵州省科技计划基金资助项目[黔科合SY(2010)3079号]

摘　　要：目的:观察丙泊酚对脑损伤术后血浆β-内啡肽(β-EP)、血清热休克蛋白70(HSP70)、血乳酸及血糖水平的影响。方法:90例脑损伤开颅术后病人随机分成对照组和丙泊酚组,测定两组病人转入ICU即刻、转入后24、48以及72 h血浆β-EP值、血清HSP70及血乳酸值,并测定转入即刻至转入后72 h内每4 h的血糖值。结果:与对照组比较,转入后24、48和72 h丙泊酚组患者β-EP、HSP70和血乳酸值降低,差异有统计学意义(P<0.05);转入后第一个4 h,对照组患者血糖值(11.58±2.65)mmol/L高于丙泊酚组患者血糖值为(9.61±1.71)mmol/L,差异有统计学意义(P=0.024)。结论:脑损伤应激反应过程中应用丙泊酚,可降低相关应激指标的水平,增加机体对应激的调控。Objective：To observe the effects of propofol onβ-endorphin（β-EP）,heat shock protein 70（ HSP70 ）,blood lactatic acid,blood glucose in patients after craniocerebral injury surgery. Methods：90 patients with brain injury after craniotomy were randomly divided into control group and propofol group. The β-EP value,HSP70 and lactic acid were tested at the moment the patient was transferred into intensive care unit（ICU）immediately and at 24,48 and 72 hours later,and the blood glucose was tested every 4 hours. Result：At 24,48 and 72 hours later,the β-EP,HSP70 and blood lactic acid levels of propofol group were significantly lower than that in control group,difference was statistically significant（P〈0. 05）. The first 4 hours after transfer into ICU,the blood glucose levels of control group（11. 58 ±2. 65）mmol/L was higher than that of propofol group（9. 61±1. 71）mmol/L, difference was statistically significant（ P=0 . 024 ）. Conclusion：Propofol can reduce the levels of β-EP,HSP70,blood lactatic acid and blood glucose in the course of stress reaction after traumatic brain injury operation and enhance the adjustment of stress reaction of human body.

关 键 词：丙泊酚 脑损伤 应激 乳酸 Β-内啡肽 热休克蛋白70 

分 类 号：R651.15[医药卫生—外科学]