高强度聚焦超声联合中药扶正消瘤方治疗子宫肌瘤的研究  

Study on high-intensity focused ultrasound combined with Chinese medicine Fuzheng Xiaoliu Decoction in treatment of uterine fibroid

作　　者：胡红[1] 许芙蓉[2] 但汉丽[2] 吕君[2] 魏薇[1] 曾智鸿[1] 江书碧[1] 

机构地区：[1]重庆市江北区中医院特检科,400020 [2]重庆市江北区中医院妇产科,400020

出　　处：《重庆医学》2016年第32期4496-4498,共3页Chongqing medicine

基　　金：卫生部临床科研合作项目(MWHT-13-HZ001);重庆市卫计委中医药科技项目(ZY20150208);重庆市卫计委医学科研项目(2016MSXM132)

摘　　要：目的评价高强度聚焦超声(HIFU)联合中药扶正消瘤方治疗子宫肌瘤的临床疗效。方法 110例子宫肌瘤患者191个病灶采取HIFU联合中药扶正消瘤方治疗3个月,通过经阴道彩超观察比较治疗前后子宫肌瘤回声、体积及血流灌注的改变情况,进行统计学相关分析。结果子宫肌瘤患者经HIFU联合中药扶正消瘤方治疗前后,肌瘤内部回声发生明显变化,靶区内出现不均质高回声增强区域,术后3个月还可出现液化坏死或钙化高回声;治疗后肌瘤体积明显变小,肌瘤周边滋养血管的搏动指数(PI)、阻力指数(RI)明显增加,Adler半定量血流分级显示血流灌注明显减少,差异有统计学意义(P<0.05)。结论 HIFU联合中药扶正消瘤方治疗子宫肌瘤可导致肿瘤大小和血流参数发生明显变化,经阴道彩超可以无创性动态评价其疗效。Objective To evaluate the clinical effect of high-intensity focused uttrasound（HIFU） combined with Chinese medicine Fuzheng Xiaoliu Decoction in the treatment of uterine fibroid. Methods One hundred and ten cases（191 lesions） of uterine fibroid adopted the treatment of HIFU combined with Chinese medicine Fuzheng Xiaoliu Decoctio for 3 months. The changes of u- terine fibroid echo,volume and blood perfusion observed by transvaginal color Doppler ultrasound were compared between before and after treatment and performed the statistical correlation analysis. Results The internal echo of uterine fibroid after the treat- ment of HIFU combined with Chinese medicine Fuzheng Xiaoliu Decoction had obvious change, the heterogeneity high-echo en- hancement area appeared in the targeted area, liquefactive necrosis and calcification high echo could appear at postoperative 3 months; the tumor volume after treatment was diminished significantly,the pulse index （PI） and resistance index（RI） of peritumor nourishing vessels were increased significantly. The Adler semi-quantitative blood flow grade showed that intra-tumor blood perfu- sion was reduced significantly（P〈0.05）. Conclusion HIFU combined with Chinese medicine Fuzheng Xiaoliu Decoction can result in significant changes of tumor size and intra-tumor blood flow parameters of uterine fibroid. The transvaginal color Doppler ultra- sound can non-invasively evaluate its curative effect.

关 键 词：高强度聚焦超声 超声检查 多普勒 彩色 子宫肌瘤 中药 

分 类 号：R737.33[医药卫生—肿瘤]