普萘洛尔治疗婴幼儿血管瘤过程中致腹泻的机制探讨  

Study of mechanism of diarrhea resulted from oral propranolol treatment of infantile hemangioma

作　　者：刘海金[1] 陶超[2] 黄海金[1] 许露[1,3] 刘金平[1] 徐仙贇[2] 彭威[1] 刘潜[1,2] 

机构地区：[1]赣南医学院第一附属医院小儿外科/江西省脉管性疾病临床研究中心,江西赣州341000 [2]赣南医学院,江西赣州341000 [3]广东省妇幼保健医院新生儿科,广东广州511400

出　　处：《重庆医学》2016年第32期4514-4516,共3页Chongqing medicine

基　　金：江西省赣鄱英才"555工程"创新人才项目[赣才字(2012)1号];人力资源与社会保障部2011年度留学人员科技启动项目[赣人社字(2011)474号];江西省自然科学基金资助项目(2010GZY0016)

摘　　要：目的 探讨普萘洛尔治疗婴幼儿血管瘤过程腹泻发生率、严重程度及后续处理。方法 对213例口服普萘洛尔治疗的婴幼儿血管瘤患儿进行回顾性分析,按腹泻严重程度进行区分,记录相应处理和预后。结果 腹泻发生率为16.9%,其中轻中度13.2%,占腹泻发生率的91.6%;腹泻28例出现在服药后的前3d（药量递增的3d）,8例发生在服药后的4-6d;腹泻69.4%持续1-3d可自行缓解,91.6%持续4-6d缓解,极少严重腹泻者需对症处理后缓解或停药处理;0-3、〉3-6、〉6个月以上3阶段腹泻发生情况组间差异无统计学意义（P〉0.05）。结论 普萘洛尔治疗婴幼儿血管瘤过程中腹泻的发生率较高,多数腹泻较轻,可耐受继续用药,但严重的腹泻建议及时停药。Objective To study the incidence rate, severity and subsequent treatment of diarrhea occurred during the process of oral propranolol for treating infantile hemangioma. Methods A total of 213 cases oral propranolol for treating infantile hemangi- oma were analyzed retrospectively and were grouped accordiing to the severity of diarrhea. The corresponding management and prog- nosis of diarrhea were recorded. Results The incidence rate of diarrhea was 16.9%. Among them,the incidence rate of the mild and moderate one was 13.2 %, accounting for 91.6 % of diarrhea incidence rate. The diarrhea symptoms in 28 eases appeared on the first 3 d after medication （ on 3 d with the gradually increasing propranolol dose ）, while which in 8 cases occurred on 4-6 d after medi- canon;diarrhea could be spontaneously relieved after 1 3 d sustaming in 69.4% of the cases,91.6% of the cases lasted for 4-6 d and then relieved. Few cases of severe diarrhea needed symptomatic treatment for relief or drug withdrawal for treatment. The diar- rhea severity had no statistical difference among the age groups of 0-3 months. 3-6 months and 6 months above（P〈0.05）. Con- clusion The diarrhea incidence rate is higher during propraootol treatment process of infantile hemangloma. Most diarrheas are mild, and can be tolerated to continue the medication.but severe diarrhea ts recommended to timely discontinue medication.

关 键 词：血管瘤 普萘洛尔 不良反应 腹泻 婴幼儿 

分 类 号：R732.2[医药卫生—肿瘤]