氯吡格雷联合拜阿司匹林治疗重度颈动脉狭窄临床效果观察  

The clinical efffect of clopidogrel combined with aspirin in the treatment of severe carotid artery stenosis

作　　者：罗晓静[1] 白良[1] 杨成蓉[1] 

机构地区：[1]四川省雅安市人民医院神经内科,625000

出　　处：《临床合理用药杂志》2016年第32期3-4,16,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察重度颈动脉狭窄患者采用氯吡格雷与拜阿司匹林联合用药治疗的临床效果。方法选取医院进行治疗的患有重度颈动脉狭窄但拒绝行血管内治疗的患者74例作为研究对象,随机分为对照组和试验组,每组37例。对照组采用阿托伐他汀与拜阿司匹林联合用药治疗,试验组采用氯吡格雷与拜阿司匹林联合用药进行治疗。观察2组患者在用药治疗1年后的相关病症发生情况及对治疗效果的满意程度。结果试验组短暂性脑缺血及再发脑梗死发生率分别为8.11%、2.70%,低于对照组的27.03%、16.22%(P均<0.05);但2组脑出血发生率比较差异无统计学意义(P>0.05)。试验组患者治疗总满意度为91.89%,高于对照组的72.97%(P<0.05)。结论采用氯吡格雷与拜阿司匹林联合用药治疗重度颈动脉狭窄临床效果显著,可广泛推广应用。Objective To observe the clinical efffect of elopidogrel combined with aspirin in the treatment of severe carotid artery stenosis. Methods 74 cases of patients with severe carotid artery stenosis but refused treatment of endovaseular were selected as the research object in our hospital, and they were randomly divided into control group and experimental group, 37 cases in each group. The control group were treated with atorvastatin statins and aspirin combination therapy, while the ex- perimental group were treated with atorvastatin and clopidogrel and aspirin combination therapy. After the treatment, compared the clinical curative effect of two patients in the treatment group. Results The transient isehemie attack rate and recurrence rate of cerebral infarction in the experimental group was 8.11% ,2.70%, which was significantly lower than 27.03 %, 16.22% of the control group（ P 〈 0.05 ）. But there was no significant difference of cerebral hemorrhage between the two groups （P 〉 0. 05）. In addition, The total satisfaction of the patients in the experimental group was 91.89%, which was higher than 72. 97% in the control group（P 〈 0.05 ）. Conclusion The clinical effect of clopidogrel combined with worship aspirin is sig nificantly in the treatment of severe carotid artery stenosis, which can widely popularized and applied.

关 键 词：氯吡格雷 拜阿司匹林 阿托伐他汀 重度颈动脉狭窄 临床效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]