肿瘤代谢重编程中的癌基因与抑癌基因  

Role of oncogene and tumor suppressor gene in tumor metabolic reprogramming

作　　者：徐欣元[1] 沈岚[1] 药立波[1] 

机构地区：[1]第四军医大学基础医学院,陕西西安710032

出　　处：《中国生化药物杂志》2016年第9期1-5,共5页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目前对肿瘤特有的代谢模式的认识日益广泛深入,尤其是肿瘤细胞代谢重编程的过程和机制受到关注。癌基因与抑癌基因在影响肿瘤发生发展的过程中也不断改变着肿瘤的物质代谢途径和流量,使之适应肿瘤生长需求。本文讨论c-MYC、TP53、HIF-1α等癌基因或抑癌基因及其相关通路在肿瘤代谢重编程中的作用。With the understanding of tumor metabolism,the process and mechanism of tumor metabolic reprogramming gradually attracted much attention in recent years. Oncogenes and tumor suppressor genes are constantly changing the pathway and flux of tumor metabolism in tumorigenesis to meet the needs of tumor growth and proliferation. The role of c-MYC,TP53,HIF-1α as well as the related signal pathways in tumor metabolic reprogramming would be discussed.

关 键 词：肿瘤 代谢重编程 癌基因 抑癌基因 

分 类 号：R730[医药卫生—肿瘤]