抗血小板聚集药物对上消化道出血患者的临床病症及影响因素分析  

Analysis of clinical symptoms and influencing factors of anti-platelet aggregation drugs in patients with upper gastrointestinal bleeding

作　　者：郑东阳[1] 颜丽卿 张卓群[2] 潘金水[3] 

机构地区：[1]厦门大学附属第一医院消化内科,福建厦门361022 [2]厦门大学附属第一医院消化内镜室,福建厦门361022 [3]厦门大学附属中山医院消化内科,福建厦门361022

出　　处：《中国生化药物杂志》2016年第9期141-143,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：福建省卫生系统中青年骨干人才培养项目(2013-ZQN-ZD-33)

摘　　要：目的抗血小板聚集药物对上消化道出血患者临床病症及影响因素分析。方法采用回顾性分析的研究方法,收集2012年6月-2015年6月入厦门大学附属第一医院治疗消化道出血的110例患者资料,分为2组,对照组79例未服用抗血小板聚集药物治疗,实验组31例服用单一抗血小板聚集药物治疗,观察2组患者的消化道出血程度、出血方式,以及在内镜下表现的特征,参照每位患者的年龄、INR值,服用的药物类型,进一步分析该类药物对上消化道出血患者的临床病症和影响因素。结果实验组消化道出血严重率明显高于对照组（P〈0.05）,患者年龄越大,消化道出血率越高,在内镜下主要表现为胃炎或溃疡,INR〉3的患者消化道出血严重率明显高于INR〈3的患者。结论抗血小板聚集药物会明显增加消化道严重出血的机率,患者年龄及药物种类均能影响消化道出血的发生率;长期使用该类药物对十二指肠的影响最为严重,可导致该部位肠粘膜受损;随患者年龄增大,患者消化道的不良反应增大。Objective To analysis of clinical symptoms and influencing factors of anti-platelet aggregation drugs in patients with upper gastrointestinal bleeding. Methods Using the research methods of retrospective analysis,collected 110 cases of gastrointestinal bleeding patients from June 2012 to June 2015 into the first affiliated hospital of xiamen university,and divided into two groups,the control group,79 patients were treated without antiplatelet aggregation drugs,the experimental group,31 patients were treated with single antiplatelet aggregation drug. observed the degree of gastrointestinal bleeding,the mode of bleeding,and the characteristics of endoscopic findings between two groups,according to the age,INR,and the type of drug taken,the clinical symptoms and influencing factors of the patients were analyzed further. Results The rate of gastrointestinal bleeding was significantly higher in the experimental group than in the control group（P〈0. 05）. The older the patient,the higher rate of gastrointestinal bleeding,the main manifestations were gastritis or ulcers in endoscopy,patients with INR〉 3 had a significantly higher rate of gastrointestinal bleeding than patients with INR 〈3. Conclusion Anti-platelet aggregation drugs can significantly increase the chance of serious bleeding in the digestive tract,the patient＇s age,INR value and the type of medication can affect the incidence of gastrointestinal bleeding; long-term use of these drugs lead the most serious impact on the duodenum,can lead to the site intestinal mucosa damage,with the increasing age of patients,adverse reactions of the digestive tract increased.

关 键 词：抗血小板聚集药物 消化道出血 INR值 内镜检查 

分 类 号：R571[医药卫生—消化系统]