上消化道症状与幽门螺杆菌感染及胃癌前疾病的相关性  

Correlation of upper gastrointestinal symptoms between Helicobacter pylori infection and gastric precancerous disease

作　　者：谢琼[1] 卢月月[1] 易宏锋[1] 

机构地区：[1]湖北省荆州市第一人民医院消化内科,荆州市434000

出　　处：《中华实验和临床感染病杂志（电子版）》2016年第3期319-322,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的探讨上消化道症状与幽门螺杆菌(HP)感染及胃黏膜癌前病变的相关性。方法选择2013年1月至2014年10月于本院门诊初诊为慢性胃炎的患者,其中上消化道症状阳性组的患者360例,上消化道症状阴性组患者360例,所有患者均通过碳14呼气试验进行HP检测及胃镜下活检,分别比较有无上消化道症状与患者HP阳性检出率的相关性;以及有无上消化道症状与胃镜活检诊断为胃癌前疾病的相关性。结果上消化道症状阳性组患者HP检出率高于上消化道症状阴性组(χ2=353.892、P=0.000);上消化道症状阳性组患者慢性胃炎伴不典型增生发病率显著高于上消化道症状阴性组,差异具有统计学意义(χ2=12.328、P=0.000)。结论上消化道症状与HP感染具有相关性,上消化道症状与慢性胃炎伴不典型增生具有相关性。Objective To explore the correlation of gastrointestinal symptoms, Helicobacter pylori（HP） infection and gastric precancerous diseases. Methods Patients diagnosed as chronic gastritis were selected from January 2013 to October 2014. Then the patients were divided into upper gastrointestinal symptoms of positive group（360 cases） and negative group（360 cases）. All patients were tested by 14 C breath test and diagnosised with biopsy in endoscopy. The relationship between the upper gastrointestinal symptoms in patients with HP positive rate and the upper gastrointestinal symptoms with endoscopy biopsy diagnosis of precancerous disease were compared, respectively. Results The HP detection rate of upper gastrointestinal symptoms positive group was significantly higher than that of negative group（χ^2 = 353.892, P = 0.000）. The incidence of chronic gastritis with symptoms of upper gastrointestinal dysplasia positive group was significantly higher than that of negative group（χ^2 = 12.328, P = 0.000）. Conclusions Upper gastrointestinal symptoms was correlated with HP infection, and there were relevantion between upper gastrointestinal symptoms and chronic gastritis.

关 键 词：幽门螺杆菌 上消化道症状 胃癌前疾病 相关性 

分 类 号：R735.2[医药卫生—肿瘤]