2005至2013年首都医科大学附属北京地坛医院住院肝病患者肝病疾病谱变化及相关因素分析  

Changes of liver diseases spectrum and the risk factors in Beijing Ditan Hospital, Capital Medical University from 2005 to 2013

作　　者：欧蔚妮[1] 付艳[2] 邢卉春[1] 成军[1] 

机构地区：[1]首都医科大学附属北京地坛医院肝病中心,北京100015 [2]山东省济宁医学院附属医院感染科,济宁市272000

出　　处：《中华实验和临床感染病杂志（电子版）》2016年第3期327-332,共6页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：中医药发展基金项目(No.2014ZX10005001);国家自然科学基金资助项目(No.81201160)

摘　　要：目的探讨近年来影响人类健康的主要肝病疾病谱及其变化趋势,以及乙型肝炎病毒性相关性原发性肝癌的临床流行病学及临床特征,旨在为肝病的防治可靠的循证医学依据。方法收集2005年1月至2013年12月9年间,本院住院的、出院主要诊断为肝病且人口学资料及临床资料齐全的患者,应用SPSS 16.0统计软件回顾性分析各种肝病的构成比及逐年变化;进一步分析乙型病肝炎毒性相关的原发性肝癌的流行病学资料(包括乙型病毒性、感染史、家族史、输血史、饮酒史)及接受抗病毒治疗的相关资料。结果回顾性分析发现,此9年间,本院住院的肝病患者的疾病谱,仍以病毒性肝病,尤其是乙型肝炎病毒相关性肝病为主。肝恶性肿瘤患者数量及构成比呈上升趋势;多数患者发现肝癌前未接受抗病毒治疗,或就诊时已出现远处转移。经抗病毒治疗后,肝癌患者有较好的预后。结论本研究发现近年来,住院的肝脏病患者中,乙型肝炎病毒相关性疾病,尤其是原发性肝癌患者的构成比呈现上升趋势。经抗病毒治疗的HBV相关性原发性肝癌患者预后相对较好。Objective To explore the main kinds of liver diseases which threat human health in recent years and also discuss clinical epidemiology and features of HBV associated with primary carcinoma of the liver, conducted to find reliable evidence-based medicine values. Methods The demographic characteristics and clinical features of hospitalized patients with liver disease from January 2005 to December 2013 in our hospital were collected, whose first diagnosis were hepatopathy with complete demographic and clinical data. The spectrum changes of liver diseases, the clinical feature and anti-virus therapy for patients with HBV related primary carcinoma of the liver were analyzed prospectively by SPSS 16.0 software. Results During the 9 years, patients with viral related liver diseases, especially HBV associated liver diseases occupied the majority constituent ratio in all hospitalized patients with liver diseases. The ratio of patients with HBV related primary carcinoma of the liver was on the rise. Most of them did not receive anti-viral therapy before the primary carcinoma of the liver diagnosed, or with cancer transfer to far place as the primary carcinoma of the liver was diagnosed. After antiviral treament, patients of primary carcinoma of the liver had better prognosis. ConclusionsIn recent years, among inpatients, the ratio of HBV associated liver diseases,especially primary carcinoma of the liver, presented an upward trend. The ones who received anti-virus treatment could get better prognosis.

关 键 词：肝病 疾病谱 原发性肝癌 抗病毒治疗 

分 类 号：R575[医药卫生—消化系统]