美沙拉嗪缓释颗粒剂不同用药方式在轻-中度溃疡性结肠炎中的临床疗效  

Effect of different methods of Mesalazine sustained-release granules in the treatment of mild to moderate active ulcerative colitis

作　　者：马士杰[1] 罗小玲[1] 谢睿[1] 潘峰[1] 李倩君[1] 周传文[1] 

机构地区：[1]南京医科大学附属淮安第一医院消化科,江苏淮安223300

出　　处：《胃肠病学和肝病学杂志》2016年第11期1305-1307,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨美沙拉嗪缓释颗粒剂不同用药方式治疗轻-中度溃疡性结肠炎(ulcerative colitis,UC)的临床疗效。方法选择南京医科大学附属淮安第一医院2013年1月-2015年10月收治的120例轻-中度UC患者,随机分为A组(n=40)、B组(n=40)和C组(n=40),所有患者均给予美沙拉嗪缓释颗粒剂治疗,A组1次/d,4 g/次;B组2次/d,2 g/次;C组4次/d,1 g/次。治疗8周后比较三组患者的临床疗效、用药依从性及不良反应发生情况。结果 A组、B组、C组总有效率、黏膜愈合率比较差异无统计学意义(P>0.05);A组用药依从性优于C组(P<0.05)。三组不良反应发生率比较,差异无统计学意义(P>0.05)。结论美沙拉嗪缓释颗粒剂顿服与分次服用具有相近的临床疗效,但顿服可显著提高患者的用药依从性,且并未增加患者不良反应的发生,值得临床重视。Objective To investigate the effect of different methods of Mesalazine sustained-release granules in me treatment of mild to moderate active ulcerative colitis （UC）. Methods One hundred and twenty patients with mild to moderate UC in the First Affiliated Hospital of Nanjing Medical University from Jan. 2013 to Oct. 2015 were selected as the objects, they were randomly divided into group A （n = 40） , group B （n = 40） and group C （n = 40） , all patients were treated with Mesalazine sustained-release granules, group A received Mesalazine sustained-release granules 4 g once daily, group B received 2 g each time and twice daily, group C received 1 g each time and four times daily. After 8 weeks of treatment, the clinical efficacy, the medication compliance and the adverse reaction were compared among three groups. Results The total effective rate and mucosa] healing rate were no significant difference among three groups （P 〉 0.05）. Medication compliance was better in group A than that in group C （P 〈 0.05）. The adverse reac- tion rate was no significant difference among three groups （P 〉 0.05）. Conclusion Mesalazine sustained-release gran- ules release granules in divided doses and meal served in the treatment of mild and moderate ulcerative colitis have simi- lar clinical efficacy, but the meal service can significantly improve the medication compliance of patients and do not in- crease the occurrence of adverse reactions in patients, it is worthy of attention.

关 键 词：溃疡性结肠炎 美沙拉嗪缓释颗粒剂 用药方式 临床疗效 

分 类 号：R574.62[医药卫生—消化系统]