患有脂肪肝的老年人合并动脉粥样硬化风险升高  

Senior People with Nonalcoholic Fatty Live Had Higher Risk of Atherosclerosis

作　　者：郑佳萍[1] 叶华[1] 严金柱[1] 吴美娜[1] 王小勇[1] 黄鸿旗[1] 

机构地区：[1]福建省级机关医院,福建福州350000

出　　处：《中外医学研究》2016年第32期7-9,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨老年患者脂肪肝与动脉粥样硬化的关系。方法:对2014年5月-2015年5月笔者笔者所在医院年龄大于65岁的体检者进行腹部B超检查,参考《中国非酒精下脂肪性肝病诊疗指南2010年修订版》,将其分为脂肪肝组和对照组,对比两组颈动脉内膜厚度,两组颈动脉粥样硬化、冠状动脉粥样硬化、下肢动脉粥样硬化、心肌缺血(在心电图上体现为ST段压低)的患病率。结果:共入组117例,其中脂肪肝组70例,对照组47例,脂肪肝组中合并冠状动脉粥样硬化及下肢动脉粥样硬化的人数均为27例,患病率为38.57%,明显高于对照组(分别为9例和8例,患病率分别为19.15%及17.12%),差异有统计学意义(P=0.040、0.014);脂肪肝组的颈动脉内膜厚度(10.93±0.91)mm,高于对照组的(10.11±1.03)mm,差异有统计学意义(P<0.001);脂肪肝组合并心电图ST段压低的比率42.86%,高于对照组的14.90%,差异有统计学意义(P=0.020)。结论:老年脂肪肝患者颈动脉内膜厚度数值升高,同时冠状动脉粥样硬化、下肢动脉粥样硬化、心肌缺血的发病风险增高。Objective： To explore the relationship among nonalcoholic fatty liver disease and atherosclerosis in senior people.Method： B ultrasound of abdomen were took out for people with age above 65 years ago from May 2014 to May 2015.According to （Guidelines for management of nonalcoholic fatty liver disease： an updated and revised edition the Chinese National Workshop on Fatty Liver and Alcoholic Liver Disease for the Chinese Liver Disease Association）, they were divided into fatty liver group and control group.T-test was used to compare the carotid intima-media thickness between two groups, and Chi-square test was used to compare the prevalence of carotid atherosclerosis, coronary atherosclerosis, lower extremity atherosclerosis and myocardial ischemia（which was evaluated by the ST-segment depression in ECG） between two groups.Result： 117 persons were enrolled, including 70 persons for fatty liver group and 47 persons for control group.The prevalence of coronary atherosclerosis, lower extremity atherosclerosis and ST-segment depression were higher in fatty liver group（38.57% compared to 19.15%, P=0.040 ; 38.57% compared to 17.12%, P=0.014 ; 42.86% compared to 14,90%, P=0.020）, and patients with fatty liver had higher value of carotid intima-media thickness compared to control group[（10.93± 0. 91）mm compared to （10.11 ± 1.03）mm, P〈0.001].Condusion： Senior patients with fatty liver disease have higher value of carotid intima-media thickness, and higher risks of coronary atherosclerosis, lower extremity atherosclerosis, myocardial ischemia.

关 键 词：老年 脂肪肝 颈动脉内膜厚度 动脉粥样硬化 ST段压低 

分 类 号：R575.5[医药卫生—消化系统] R543.5[医药卫生—内科学]