运用Keratograph 5M眼表综合分析仪评价干眼患者的泪膜及睑板腺功能  

Evaluation of tear film and meibomian gland function in dry eye patients using Keratograph 5M

作　　者：诸科璇 谢文加[1] 应靖璐[1] 姚玉峰[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院眼科

出　　处：《浙江大学学报（医学版）》2016年第4期422-428,共7页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的：使用Keratograph 5 M眼表综合分析仪测定干眼患者的泪膜功能，并运用睑板腺照相评分系统评估睑板腺功能。方法：选取干眼患者及健康对照组各72只眼，所有检查者均先后完成以下检查：眼表疾病指数（ OSDI ）问卷评估眼部症状；Keratograph 5 M 测量下睑中央泪河高度（ TMH ）、非侵袭泪膜破裂时间（ NIBUT）包括首次NIBUT和平均NIBUT、上下睑板腺红外线照相评分；传统荧光素钠染色方法测量荧光素钠泪膜破裂时间（ FBUT）。结果：干眼组OSDI问卷评分高于健康对照组，而TMH、首次NIBUT、平均NIBUT值均低于健康对照组，差异均有统计学意义（均P＜0．01）。干眼组的睑板腺照相评分总分高于健康对照组，差异均有统计学意义（均P＜0．01）；上下睑总分与首次NIBUT、平均NIBUT显著相关（r＝－0．449、－0．398，均P＜0．01），与年龄无相关性（r＝0．031，P＞0．05）。首次NIBUT、平均NIBUT与FBUT均显著相关（r＝0．833、0．727，均P＜0．01）。结论：使用Keratograph 5 M眼表综合分析仪能简便、准确、非侵袭性地评价干眼患者的泪膜及睑板腺功能；睑板腺照相评分系统能较全面、客观、简便地评价睑板腺功能。Objective： To assess the application of Keratograph 5M in evaluating tear film and meibomian gland function in patients with dry eye.Methods： A total of＆amp;nbsp;144 eyes were recruited in the study, in which 72 eyes were from patients diagnosed with dry eye and 72 eyes were from healthy subjects.All subjects finished following tests or examinations：ocular surface disease index （ OSDI） to evaluate eye symptoms;Keratograph 5M examination to obtain tear meniscus height （TMH）, noninvasive tear break-up time （ NIBUT ） including first NIBUT （ NIBUT-Fir ） and average NIBUT （ NIBUT-Ave） , and infrared meibography; and fluorescein sodium staining to obtain fluorescein tearbreak-up time （ FBUT） .Results：Dry eye group had higher OSDI score than healthy control group, but its TMH, NIBUT-Fir and NIBUT-Ave were lower than those in healthy control group （all P〈0.01）.Total meiboscore in dry eye group was higher than that in healthy control group （ P 〈0.01 ） , and it showed a significant correlation with NIBUT-Fir and NIBUT-Ave （r=-0.449 and -0.398, P〈0.01）, but no correlation with ages was observed （r=0.031, P〉0.05）.The NIBUT-Fir and NIBUT-Ave showed a significant correlation with FBUT （ r=0.833 and 0.727, P〈0.01）.Conclusion： Keratograph 5M is a convenient, accurate and non-invasive method to assess the function of tear film and meibomian gland, and the new meibography scoring system can evaluate the function of meibomian gland objectively and succinctly.

关 键 词：干眼病/诊断 诊断技术 眼科/仪器和设备 睑板腺 问卷调查 

分 类 号：R777.34[医药卫生—眼科]