代谢组学在中药治疗肾脏疾病及中药毒性研究的应用与进展  

Application and progress of metabolomics in nephropathy treatment with traditional Chinese medicine and related toxicity study

作　　者：陈淋[1] 陈丹倩 赵辉[1] 卢丰林 陈华[1] 赵英永[1] 

机构地区：[1]西北大学生命科学学院,西安710069

出　　处：《药物分析杂志》2016年第11期1897-1903,共7页Chinese Journal of Pharmaceutical Analysis

基　　金：教育部"新世纪优秀人才计划"项目(NCET-13-0954);国家自然科学基金(81673578;81603271);国家十二五"重大新药创制"专项(2014ZX09304307-002)

摘　　要：随着代谢组学不断发展,其在中药领域的应用越来越广泛。基于代谢组学在中药领域的应用,本文综述了中药治疗肾脏疾病及中药毒性研究文献,为阐明中药治疗肾脏病的生物化学作用机理及中药毒性机制,发掘治疗肾脏病新药物及提高用药安全性等提供参考。The development of metabolomics has brought it＇s wider application in the field of traditional Chinese medicine （ TCM ） in recent years. Based on the application of metabolomics in TCM, this review summarized the treatment of kidney disease with TCM and the toxicity of TCM, and provided reference to biochemical action mechanism of kidney disease treatment with TCM and its toxicity mechanism, as well as to the development of novel drugs for kidney disease treatment and improving drug safety.

关 键 词：代谢组学 系统生物学 中药 肾脏病治疗 毒副作用 生物标示物 

分 类 号：R917[医药卫生—药物分析学]