雷珠单抗治疗不同疾病所致黄斑水肿的疗效观察  

Clinical observation of Ranibizumab for macular edema caused by various diseases

作　　者：寇豆 郝晓琳[2] 张仲臣[2] 

机构地区：[1]锦州医科大学研究生学院,中国辽宁省锦州市121001 [2]航天中心医院眼科,中国北京市100049

出　　处：《国际眼科杂志》2016年第12期2272-2275,共4页International Eye Science

基　　金：中国航天科工集团公司2014年医疗卫生科研项目(No.2014-LCYL-006)~~

摘　　要：目的:探讨玻璃体腔注射雷珠单抗治疗因糖尿病、视网膜静脉阻塞继发黄斑水肿的安全及有效性。方法:选取2013-06/2016-02在北京航天中心医院眼科因糖尿病继发黄斑水肿(DME)和视网膜静脉阻塞继发黄斑水肿(RVO-ME)收治入院,并符合本研究纳入及排除标准的患者35例38眼,其中DME 23眼,RVO-ME 15眼。患眼接受玻璃体腔雷珠单抗(0.5mg/0.05m L)注射治疗,治疗前和治疗后1、3d,1wk、1mo定期门诊回访观察最佳矫正视力(BCVA)、黄斑中心凹厚度(CRT)、眼压。比较雷珠单抗治疗DME及RVO-ME前后的疗效。结果:DME组及RVO-ME组治疗后1、3d,1wk的BCVA均较治疗前提高,差异均有统计学意义(P<0.05),而两组1mo的BCVA与治疗前相比差异均无统计学意义(P>0.05)。DME组及RVO-ME组治疗后1、3d,1wk,1mo的CRT均较治疗前明显改善,差异均有统计学意义(P<0.05)。在BCVA及CRT方面比较,雷珠单抗对于RVOME及DME疗效差异无统计学意义(P>0.05)。结论:玻璃体腔注射雷珠单抗对DME及RVO-ME的治疗均安全有效。AIM：To identify the effective and safety of ranibizumab intravitreal injection in patients with macular edema（ M E） caused by diabetic macular（ DM） and retinal vein obstruction（ RVO）.METHODS： Thirty- eight eyes of thirty- five patients was retrospectively evaluated, twenty- three with M E caused by DM and fifteen with RVO, who received intravitreal ranibizumab（ 0. 5mg /0. 05 ml） and were followed up for at least a month.,The best corrected visual acuity（ BCVA）,central retinal thickness（ CRT）and intraocular pressure（ IOP） were followed up at 1,3d,1wk and 1mo respectively. The effect of the DM E and RVO-M E were compared.RESULTS： DM E and RVO- M E group after treatment in1,3d,1wk,the BCVA were obviously improved,and the differences were statistically significant（ P 〈0. 05）. But compared the BCVA in 1mo with before showed no statistically significant difference（ P〉0. 05）. DM E and RVO-M E group after treatment in 1,3d,1wk and 1mo,CRT was obviously improved,and the differences were statistically significant（ P〈0. 05）. The BCVA and CRT of treatment showed no statistically significant difference between DM E with RVO-M E（ P〉0. 05）. CONCLUSION： Bevacizumab intravitreal injection for M E caused by DM and RVO was safe and effective.

关 键 词：雷珠单抗 糖尿病黄斑水肿 静脉阻塞黄斑水肿 

分 类 号：R774.5[医药卫生—眼科]