曲伏前列素滴眼液治疗原发性开角型青光眼和高眼压症  

Travoprost drops solution in the treatment of primary open-angle glaucoma and ocular hypertension

作　　者：朱海平[1] 邓德勇[1] 谢美娜[1] 

机构地区：[1]武警浙江省总队医院嘉兴医院眼科,中国浙江省嘉兴市314000

出　　处：《国际眼科杂志》2016年第12期2314-2316,共3页International Eye Science

摘　　要：目的:研究曲伏前列素滴眼液治疗原发性开角型青光眼和高眼压症的降眼压效果及安全性。方法:随机选取2013-03/2016-03我院收治的原发性开角型青光眼和高眼压症患者80例80眼,依据不同治疗方法分为两组:曲伏前列素滴眼液组(n=40)和拉坦前列素滴眼液组(n=40),对两组患者的临床疗效、视力、散光度、眼压及不良反应发生情况进行统计分析。结果:曲伏前列素滴眼液组患者治疗的总有效率95%(38/40)显著高于拉坦前列素滴眼液组80%(32/40),差异有统计学意义(P<0.05)。曲伏前列素滴眼液组患者治疗后视力显著高于拉坦前列素滴眼液组,差异有统计学意义(P<0.05),散光度、眼压均显著低于拉坦前列素滴眼液组,差异有统计学意义(P<0.05),不良反应发生率25%(10/40)显著低于拉坦前列素滴眼液组53%(21/40),差异有统计学意义(P<0.05)。结论:曲伏前列素滴眼液治疗原发性开角型青光眼和高眼压症比拉坦前列素滴眼液具有较好的降眼压效果及较高的安全性。AIM：To study the ocular hypotensive effect and security of travoprost drops solution in the treatment of primary open-angle glaucoma and ocular hypertension.METHODS： Eighty cases（ eighty eyes） of patients with primary open-angle glaucoma and ocular hypertension in our hospital fromM ar. 2013 to M ar. 2016 were randomly selected. These patients were divided into two groups according to the treatment methods,namely travoprost drops solution group（ n = 40） and latanoprost eye drops group（ n = 40）, the clinical efficacy, visual acuity,astigmatism,intraocular pressure and adverse events of the two groups were analyzed. RESULTS： The total treatment efficiency of the travoprost drops solution group 95%（ 38 /40） was significantly higher than the latanoprost eye drops group80%（ 32 /40）（ P〈0. 05）. The eyesight was significantly higher（ P〈0. 05）,the astigmatism,intraocular pressure was significantly lower（ P〈0. 05）. The incidence of adverse reactions 25%（ 10 /40） was significantly lower than the latanoprost eye drops group 53%（ 21 /40）（ P〈0. 05）. CONCLUSION： Travoprost drops solution in the treatment of primary open- angle glaucoma and ocular hypertension has better ocular hypotensive effect and higher safety than latanoprost eye drops.

关 键 词：曲伏前列素滴眼液 原发性开角型青光眼和高眼压症 降眼压效果 安全性 

分 类 号：R775[医药卫生—眼科]