不同类型冠心病患者血浆游离脂肪酸水平变化及其与病变程度的关系  

The relationship of plasma nonesterified fatty acids levels and degree of pathological changes in patients with different types of coronary heart disease

作　　者：薛魁[1] 

机构地区：[1]江苏省邳州市人民医院检验科,221300

出　　处：《检验医学与临床》2016年第22期3171-3172,3176,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨血浆游离脂肪酸（NEFA）水平变化与冠心病（CAD）病变程度的相关性。方法选取疑为CAD患者84例,分别行生化检验和冠状动脉造影检查;根据冠状动脉造影结果将其分为4组,分别为不稳定型心绞痛组（n=46）、稳定型心绞痛组（n=9）、急性心肌梗死组（n=20）、阴性对照组（n=9）,对比组间血脂指标与NEFA是否存在差异分析,CAD患者发生急性心肌梗死风险与造影特点。结果 CAD组NEFA水平均高于阴性对照组,差异有统计学意义（P〈0.05）;急性心肌梗死组NEFA水平高于稳定型心绞痛组和不稳定型心绞痛组,差异有统计学意义（P〈0.05）;Logistic回归分析显示,校正后NEFA≥0.415mmol/L组出现急性心肌梗死的风险是NEFA〈0.415mmol/L组的2.61倍,95%CI：1.33-5.02,P〈0.05;不同水平的NEFA患者GENSINI积分、狭窄冠状动脉支数与3支冠状动脉病变数量差异无统计学意义（P〉0.05）。结论 CAD患者血浆NEFA出现升高,急性心肌梗死患者升高明显,但其与病变程度相关性未明确。Objective To investigate the relationship of plasma nonesterified fatty acids（NEFA）levels and degree of pathological changes in patients with different types of coronary heart disease（CAD）.Methods Totally 84 cases of suspected CAD were selected and all the cases underwent biochemical test and coronary angiography.According to the results of coronary angiography,the patients were divided into four groups：unstable angina group（n=46）,stable angina pectoris（SAP）group（n=9）,acute myocardial infarction group（n=20）and control group（n=9）.The level of blood lipid and NEFA were compared between the groups and risk factors of acute myocardial infarction were analysis,and coronary angiography characteristics were analyzed as well.Results The levels of NEFA in the patients with CAD were significantly higher than that of control group（P〈0.05）.The level of NEFA in acute myocardial infarction group was significantly higher than that of stable angina group and unstable angina pectoris group（P〈0.05）.Logistic regression analysis showed that risk of acute myocardial infarction of NEFA higher than 0.415mmol/L was 2.61 times higher than group of NEFA lower than 0.415mmol/L,95%CI：1.33-5.02,P〈0.05.Gensini score,the count of coronary artery stenosis and three branch of coronary artery lesions in patients with different levels of NEFA had no statistical significance（P〉0.05）.Conclusion The level of NEFA in patients with CAD is increased,especially in patients with acute myocardial infarction,but its correlation with the degree of disease is not clear.

关 键 词：冠心病 游离脂肪酸 病变程度 

分 类 号：R735.2[医药卫生—肿瘤]