变应性疾病与结直肠癌相关性的Meta分析  

Correlation between allergic diseases and colorectal cancer:a meta analysis

作　　者：张江国[1] 吕红[1] 吉明柱 

机构地区：[1]广东省深圳市蛇口人民医院消化内科,518052

出　　处：《重庆医学》2016年第33期4684-4687,共4页Chongqing medicine

基　　金：2015年度深圳市卫生计生系统科研项目基金支持(201505027)

摘　　要：目的通过Meta分析明确变应性疾病与结直肠癌发生风险及预后的关系。方法计算机检索PubMed、Medline、Embase、Web of Science、万方数据库、中国知网,时限为1988年1月至2015年10月。通过纳入及排除标准筛选文献及提取资料。采用Stata12.0软件进行Meta分析。结果共纳入16篇文献（11项队列研究、5项病例对照研究）。Meta分析结果显示,变应性疾病患者结直肠癌发生风险要明显低于对照组（OR=0.88,95%CI：0.80-0.98,P〈0.05）;分层分析发现,枯草热（OR=0.93,95%CI：0.87-0.99,P〈0.05）及变应性皮炎患者（OR=0.73,95%CI：0.56-0.95,P〈0.05）结直肠癌发生风险低于对照组。变应性疾病患者结直肠癌死亡风险明显低于对照组（OR=0.73,95%CI：0.85-0.97,P〈0.05）。结论变应性疾病患者可能通过增强免疫系统的识别能力及破坏肿瘤细胞进而降低结直肠癌发生风险及死亡风险。Objective To definite the correlation between allergic diseases with the occurrence risk and prognosis of colorectal cancer by meta analysis.Methods The databases of PubMed,MEDLINE,EMBASE,Web of Science,CNKI and Wanfang data were retrieved by computer.The time limit was from January 1988 to October 2015.The literatures were screened and the data were extracted according to the inclusion and exclusion criteria.The meta analysis was performed by using STATA12.0software.Results A total of 16articles（11cohort studies,5case-control studies）were included in this study.The meta analysis showed that the risk of colorectal cancer occurrence in the patients with allergic diseases was significantly lower than that of the control group（OR=0.88,95%CI：0.80-0.98,P〈0.05;the stratified analysis found that the risk of colorectal cancer occurrence in the patients with hay fever（OR=0.93,95%CI：0.87-0.99,P〈0.05）and patients with allergic dermatitis（OR=0.73,95%CI：0.56-0.95,P〈0.05）were lower than that of the control group.Compared with the control group,the death risk of colorectal cancer in the patients with allergic diseases was significantly lower than that of the control group（OR=0.73,95%CI：0.85-0.97,P〈0.05）.Conclusion The patients with allergic diseases may reduce the occurrence risk and death risk of colorectal cancer through enhancing the recognition ability of immune system and destroying tumor cells.

关 键 词：变应性疾病 结直肠癌 META分析 

分 类 号：R735.34[医药卫生—肿瘤]