马来酸曲美布汀与普瑞博思治疗AECOPD合并功能性消化不良伴结肠炎的体会  

Trimebutine maleate and prepulsid in the treatment of AECOPD with functional dyspepsia clinical experience with colitis

作　　者：张纳 冯学军 郑浩 

机构地区：[1]靖边县人民医院呼吸内科,陕西靖边718500 [2]靖边县人民医院普外科,陕西靖边718500

出　　处：《结直肠肛门外科》2016年第4期347-350,共4页Journal of Colorectal & Anal Surgery

基　　金：陕西省榆林市2013年度科学计划研究项目;项目编号:2013K17-1-09-65

摘　　要：目的探讨马来酸曲美布汀与普瑞博思治疗AECOPD合并功能性消化不良伴结肠炎的效果。方法选择2013年4月至2016年3月我院收治的AECOPD合并功能性消化不良伴结肠炎的患者110例,随机分为治疗组和对照组,治疗组(55例)采用口服酸曲美布汀治疗,对照组(55例)采用口服普瑞博思治疗,比较两组患者治疗后的临床疗效、临床症状总积分及主要临床症状变化。结果两组功能性消化不良伴结肠炎临床效果对比,差异无统计学意义(P>0.05);两组功能性消化不良伴结肠炎临床症状总积分及主要临床症状治疗前后组内均有显著差异(P<0.05),组间对比差异无统计学意义(P>0.05)。结论马来酸曲美布汀和普瑞博思治疗AECOPD合并功能性消化不良伴结肠炎效果相当,可减轻患者的临床症状,安全性高,适宜临床推广应用。Objective To investigate the effect of trimebutine Maleate and prepulsid in the treatment of AECOPD with functional dyspepsia clinical experience with colitis. Methods 110 colitis patients with functional dyspepsia and AECOPD from our hospital in April 2013 to March 2016 were selected and randomly divided into the experiment group and the control group.55 cases in the experiment group were treated by trimebutine maleate and 55 casses in the control group were treated by cisapride. The clinical efficacy, the clinical symptoms total score, major changes in clinical symptoms and adverse reactions were compared. Results The total effective rate of two groups had no difference（P〈0.05）.After treatment,symptoms total score and clinical symptoms of the two groups showed no significant difference（P〈0.05）. Conclusion Maleic acid trimebutine and cisapride can be effective in the treatment of functional dyspepsia with colitis and AECOPD, reduce the clinical symptoms, safe, suitable for clinical application and promotion.

关 键 词：马来酸曲美布汀 普瑞博思 功能性消化不良 结肠炎 

分 类 号：R57[医药卫生—消化系统] R563.9[医药卫生—内科学]