骨髓微环境中细胞因子影响骨髓瘤骨病的研究进展  

Progress of the impact of cytokines in bone marrow microenvironment on multiple myeloma bone disease

作　　者：刘召云[1] 付蓉[1] 

机构地区：[1]天津医科大学总医院血液内科,天津300052

出　　处：《临床血液学杂志》2016年第6期927-931,共5页Journal of Clinical Hematology

基　　金：天津市抗癌重大专项攻关计划(No:12ZCDZSY18000);天津市自然科学基金(No:14JCYBJC25400);天津市卫生计生委科技基金(No:15KG150)

摘　　要：多发性骨髓瘤（multiple myeloma,MM）是一种以恶性浆细胞克隆性增殖为特征,可引起全身多脏器功能损害的血液系统恶性肿瘤。骨病是其主要临床表现之一,包括广泛性骨质疏松、病理性骨折、脊髓压迫、高钙血症以及骨痛等,严重影响患者生存质量及预后,多种因素导致成骨与破骨细胞失衡是其主要病理机制。Multiple myeloma bone disease（ MBD） is a skeletal complication of multiple myeloma which is a hematologic malignancy of plasma cells. Multiple steps and factors contribute to the increased osteoclast activation and decreased osteoblast differentiation that lead bone disease. These factors include myeloma cell,molecules and cytokines produced by mesenchymal stem cell and bone marrow stromal cells. Here we review the current knowledge of molecules and cytokines in the bone microenvironment which induces multiple myeloma bone disease.

关 键 词：骨髓瘤骨病 微环境 细胞因子 

分 类 号：R733.3[医药卫生—肿瘤]