大黄甘草汤对重症急性胰腺炎肠黏膜屏障功能的对照研究  

Contrastive study of Dahuanggancao Decoction on intestinal mucosal barrier function in severe acute pancreatitis

作　　者：陈小鹏[1] 樊勇[1] 王跃斌[1] 陈罗飞 王琛[1] 

机构地区：[1]兰州大学第二医院普外四科,甘肃兰州730030

出　　处：《现代医药卫生》2016年第22期3432-3434,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨大黄甘草汤对重症急性胰腺炎(SAP)肠黏膜屏障功能的影响。方法将45只清洁级健康雄性SD大鼠采用随机数字表法随机分为大黄甘草汤治疗组(D组)、SAP模型组(P组)和假手术组(S组),每组15只。采用逆行注射5%牛黄胆酸钠(0.5 m L/100 g)制备大鼠SAP模型。D组给予大黄甘草汤(2.0 m L/100 g),P、S组给予0.9%氯化钠溶液(2.0 m L/100 g)。分别于建模后12、24、36 h经腹主动脉采集血标本检测血淀粉酶、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、IL-10、D-乳酸水平等。结果 D组大鼠血淀粉酶、TNF-α、IL-6、D-乳酸水平明显低于P组,IL-10水平明显高于P组,差异均有统计学意义(P<0.05)。结论大黄甘草汤对SAP大鼠肠黏膜屏障功能具有保护作用,治疗SAP疗效较好。Objective To explore the effect of Dahuanggancao Decoction on the intestinal mucosal barrier function of se-vere acute pancreatitis（SAP）. Methods Forty-five clean class SD healthy male rats were randomly divided into the Dahuanggancao Decoction group（D,n=15）,SAP model group（P,n=15）and sham operation group（S,n=15）. The SAP rat model was induced by the retrograde injection of 5%sodium taurocholate（0.5 mL/100 g）. The group D was given Dahuanggancao Decoction（2.0 m/100 g）, while the group P and S was given 0.9%sodium chloride solution（2.0 mL/100 g）. The blood samples were collected from inferior vena cava at 12,24,36 h after model construction and serum amylase,TNF-α,IL-6,IL-10 and D-lactic acid levels were detected. Results The serum amylase,TNF-α,IL-6 and D-lactic acid levels in the group D were significantly lower than those in the group P,while the IL-10 level was significantly higher than that in the group P,the difference was statistically significant（P〈0.05）. Conclusion Dahuanggancao Decoction has a protective effect on the intestinal mucosal barrier function of SAP rats and has good effect in treating SAP.

关 键 词：大黄甘草汤 急性病 胰腺炎 肠黏膜 

分 类 号：R574[医药卫生—消化系统]