青年脑梗死患者微栓子信号的观察  

Observation of Microembolic Signal of Cerebral Infarction in Young Adults

作　　者：董礼全[1] 颜丽丽 王鹏飞[1] 徐新美[1] 高犇[1] 李振光[1] 潘旭东[3] 

机构地区：[1]威海市立医院神经内科 [2]威海市立第二医院儿保科,山东省威海市264200 [3]青岛大学附属医院神经内科,山东省青岛市266000

出　　处：《中国动脉硬化杂志》2016年第11期1123-1127,共5页Chinese Journal of Arteriosclerosis

基　　金：山东省自然科学基金资助项目(ZR2011HM087)

摘　　要：目的探讨青年脑梗死患者急性期微栓子信号的特点。方法连续纳入111例青年脑梗死患者,对照组73例为同期青年健康查体人群。行微栓子信号、调节性T细胞、载脂蛋白A1、脂蛋白磷脂酶A2检测。结果青年脑梗死患者微栓子信号阳性率、载脂蛋白A1、脂蛋白磷脂酶A2水平高于对照组(28/111比0/73,P<0.05;34.57%±2.12%比27.38%±1.51%,P<0.05;255.85μg/L±10.77μg/L比137.22±8.97μg/L,P<0.05),调节性T细胞水平低于对照组(8.98%±1.27%比10.27%±1.25%,P<0.05)。不稳定斑块组微栓子信号阳性率、载脂蛋白A1、脂蛋白磷脂酶A2高于非不稳定斑块组(15/19比13/92,P<0.05;36.57%±2.32%比34.16%±1.12%,P<0.05;311.33±10.77μg/L比244.39±9.67μg/L,P<0.05),调节性T细胞低于非不稳定斑块组(7.45%±1.87%比9.30%±2.71%,P<0.05)。重度狭窄组微栓子信号阳性率、脂蛋白磷脂酶A2水平高于非重度狭窄组(7/9比21/102,P<0.05;295.23±11.37μg/L比252.38±10.07μg/L,P<0.05)。微栓子信号阳性组载脂蛋白A1、脂蛋白磷脂酶A2水平高于阴性组(36.97%±2.72%比33.76%±1.12%,P<0.05;308.21±9.57μg/L比238.19±8.92μg/L,P<0.05),调节性T细胞低于阴性组(7.49%±1.77%比9.48%±2.71%,P<0.05)。结论青年脑梗死患者急性期微栓子信号及多种免疫指标异常。Aim To investigate the characteristics of microembolic signal of cerebral infarction in young adults.Methods A total of 111 consecutive young adult patients with cerebral infarction,73 cases in the control group for the same period in healthy subjects were included in the study. All were treated with microembolic signal,regulatory T cell,apolipoprotein A1 and lipoprotein-associated phospholipase A2 detection. Results The positive rate of microembolic signal,apolipoprotein A1 and lipoprotein-associated phospholipase A2 levels of young adult patients group were higher than the control group（28/111 vs 0/73,P〈0. 05; 34. 57% ± 2. 12% vs 27. 38% ± 1. 51%,P〈0. 05; 255. 85 ± 10. 77 μg/L vs 137. 22± 8. 97 μg/L,P〈0. 05）; The level of regulatory T cell was lower than the control group（8. 98% ± 1. 27% vs 10. 27% ± 1.25%,P〈0. 05）. The positive rate of microembolic signal,apolipoprotein A1 and lipoprotein-associated phospholipase A2 levels of the unstable plaque group were higher than the non unstable plaque group（15/19 vs 13/92,P〈0. 05; 36. 57% ± 2.32% vs 34. 16% ± 1. 12%,P〈0. 05; 311. 33 ± 10. 77 μg/L vs 244. 39 ± 9. 67 μg/L,P〈0. 05）. The level of regulatory T cell was lower than the non unstable plaque group（7. 45% ± 1. 87% vs 9. 30% ± 2. 71%,P〈0. 05）. The positive rate of microembolic signal and lipoprotein-associated phospholipase A2 level of severe stenosis group were higher than that in non severe stenosis group（7/9 vs 21/102,P〈0. 05; 295. 23 ± 11. 37 μg/L vs 252. 38 ± 10. 07 μg/L,P〈0. 05）. The level ofapolipoprotein A1 and lipoprotein-associated phospholipase A2 of microembolic signal positive group were higher than negative group（ 36. 97% ± 2. 72% vs 33. 76% ± 1. 12%,P〈0. 05; 308. 21 ± 9. 57 μg / L vs 238. 19 ± 8. 92 μg / L,P〈0. 05）; The level of regulatory T cell was lower than negative group（ 7. 49% ± 1. 77% vs 9. 48% ± 2. 71%,P〈0. 05）. Conclusion There were not normal microembolic signal and immune indexes in youth patients with acute

关 键 词：青年脑梗死 微栓子信号 调节性T细胞 载脂蛋白A1 脂蛋白磷脂酶A2 

分 类 号：R741[医药卫生—神经病学与精神病学]