胃肠胰神经内分泌肿瘤淋巴结转移及生存状态影响因素分析  

An analysis of factors influencing lymph node metastasis and survival status in patients with gastroenteropancreatic neuroendocrine tumors

作　　者：崔志俊[1,2] 肖明兵[1] 杨娇娇[1] 江枫[1] 倪温慨[1] 鲍柏军[1] 陆翠华[1] 倪润洲[1] 

机构地区：[1]南通大学附属医院消化病科,江苏省226001 [2]海门市人民医院

出　　处：《江苏医药》2016年第22期2435-2437,共3页Jiangsu Medical Journal

基　　金：江苏省"六大人才高峰"资助项目(2012-WSN-O65);江苏省卫生厅资助项目(H201318);南通市科技计划资助项目(HS2014038;HS2014072)

摘　　要：目的探讨影响胃肠胰神经内分泌肿瘤(GEP-NETs)淋巴结转移及生存状态的临床病理因素。方法回顾性分析64例经病理证实的GEP-NETs患者的临床资料,分析影响淋巴结转移及患者生存状态的临床病理因素。结果 GEP-NETs患者肿瘤直径、病理类型、病理分级、浸润深度及TNM分期与淋巴结转移与否密切相关(P<0.05);年龄、肿瘤部位、病理类型、病理分级、浸润深度及淋巴结转移与患者生存状态密切相关(P<0.05)。Logistic回归分析显示,病理类型NEC、病理分级G3、浸润深度T3、T4和TNM分期Ⅲ、Ⅳ期为淋巴结转移的危险因素(OR=3.683、3.126、11.000和37.800,P<0.05);年龄>60岁、病理类型NEC、病理分级G3、浸润深度T3、T4和淋巴结转移为影响GEP-NETs患者生存的危险因素(OR=7.286、3.280、3.331、5.923和5.000,P<0.05)。结论 GEP-NETs的病理类型、病理分级及浸润深度为影响淋巴结转移及患者生存状态的共同危险因素。Objective To investigate the clinical and pathological factors influencing lymph node metastasis and survival status in the patients with gastroenteropancreatic neuroendocrine tumors （GEP-NETs）. Methods The data of 64 patients with GEP-NETs were retrospectively reviewed. Clinicopathological factors influencing lymph node metastasis and survival status were analyzed. Results Lymph node metastasis of GEP-NETs patients was closely associated with tumor diameter, pathological type, pathological grade, invasion depth and TNM stages （P〈0. 05）. The survival status of GEP-NETs patients was closely related to the age, tumor location, pathological type, pathological grade, invasion depth and lymph node metastasis（P〈0. 05）. Logistic analysis showed that pathological type NEC, pathological grade G3, invasion depth of T3, T4 and TNM stages of Ⅲ, Ⅳ were the highly risk factors for lymph node metastasis（OR= 3. 683,3. 126,11. 000 and 37. 800, P〈0. 05）. The age, tumor location,pathological type, pathological grade, invasion depth and lymph node metastasis were the risk factors influencing survival status （OR = 7. 286,3. 280,3.331,5. 923 and 5. 000, P〈0. 05）. Conclusion The pathological type, pathological grade and invasion depth are the common risk factors influencing lymph node metastasis and survival status of the patients with GEP-NETs.

关 键 词：神经内分泌肿瘤 淋巴结转移 生存状态 

分 类 号：R736[医药卫生—肿瘤]