河北省肝癌发病和死亡40年变化趋势分析  

Liver Cancer Incidence and Mortality Rates During Last 40 Years in Hebei Province

作　　者：师金 李道娟[1] 梁迪[1] 靳晶[1] 温登瑰[1] 贺宇彤[1] 

机构地区：[1]河北医科大学第四医院肿瘤研究所,石家庄050011

出　　处：《肿瘤防治研究》2016年第11期990-995,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81272682);河北省自然科学基金(C2011206058)

摘　　要：目的评估河北省肝癌的疾病负担,分析肝癌40年间的死亡率变化趋势。方法按照全国肿瘤登记中心制定的审核方法和评价标准对河北省9个登记处上报的肿瘤登记数据进行评估、审核与合并。按性别和年龄别分层,计算发病率和死亡率,以1/10万表示。分析河北省三次全死因回顾调查的肝癌数据。采用Joinpoint回归模型分析磁县肿瘤登记处1988—2012年肝癌发病和死亡趋势。结果河北省2010—2012年肝癌新发病例2 552例,死亡病例2 447例。肝癌发病率为18.26/10万(男性24.89/10万,女性11.40/10万),世标率(ASIRW)15.32/10万,占癌症发病的第五位。肝癌死亡率为17.51/10万(男性23.71/10万,女性11.09/10万),世标率(ASMRW)为15.05/10万,位于死亡顺位的第四位。河北省40年间死亡率总体上升了15.95%。磁县男女的肝癌发病和死亡趋势大致相同。结论河北省肝癌的发病率和死亡率远高于世界平均水平,河北省肝癌负担依旧严重,应继续加强肝癌防治工作。Objective To estimate the liver cancer burden and analyze the trend of the mortality rate during last 40 years in Hebei Province. Methods Cancer registry data from nine cancer registries in Hebei Province were qualified and checked according to the regulations from the National Cancer Registry Center. The pooled data were stratified by gender and age. Incidence and mortality rates were calculated and expressed in 1/100 000. Liver cancer mortality data during the three periods were extracted and calculated from the national death surveys. Mortality and incidence trends in Ci County from 1988 to 2012 were analyzed by Joinpoint Regression Models. Results The newly liver cancer cases and deaths from 2010 to 2012 in Hebei Province were 2 552 and 2 447, respectively. The crude incidence rate （CIR） of liver cancer was 18.26/100 000 （24.89/100 000 in male and 11.40/100 000 in female）. The age-standardized incidence rate by world standard population （ASIRW） was 15.32/100 000, ranking the fifth of all cancers. The crude mortality rate（CMR） of liver cancer was 17.51/100 000（23.71/100 000 in male and 11.09/100 000 in female）. The age-standardized mortality rate by world standard population（ASMRW） was 15.05/100 000, which was the fourth leading case of cancer death. The mortality rates displayed an increasing trend in Hebei Province during last 40 years as a whole, with an increased rate of 15.95%. In Ci County, the trends of incidence and mortality for both genders were similar. Conclusion The incidence and mortality rates of liver cancer in Hebei Province are much higher than the average level in the world. There is still a heavy health burden for liver cancer in Hebei Province. Thus, it is necessary to go on with taking measures to prevent and control liver cancer in the future.

关 键 词：肿瘤登记 肝癌 发病 死亡 河北省 

分 类 号：R735.7[医药卫生—肿瘤]