胰腺癌相关miRNA的研究进展  

Progress of miRNAs Related to Pancreatic Cancer

作　　者：臧毅[1] 王立夫[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院消化内科,上海200025

出　　处：《肿瘤防治研究》2016年第11期996-1000,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金面上项目(81272263)

摘　　要：胰腺癌是一种死亡率高、侵袭性强的恶性肿瘤,临床诊断和治疗目前没有较大进展。晚期确诊、早期侵袭转移和化放疗抵抗是预后差的关键因素。研究发现微小RNA的异常表达与胰腺癌有关。微小RNA是一类小非编码RNA分子,常通过降解靶基因m RNA或抑制其翻译,调控靶基因表达,从而参与肿瘤的发生发展。最新研究发现微小RNA在胰腺癌组织、血循环和其他体液中存在差异性表达,有助于胰腺癌诊断,而促癌或抑癌性微小RNA在肿瘤增殖、凋亡、进展中起重要作用,有望成为新的治疗靶点。因此,进一步深入研究胰腺癌诊断、治疗和预后相关的微小RNA,有利于从不同角度理解胰腺癌发病机制,为抗癌提供新思路。Pancreatic cancer is a malignant tumor with high mortality and strong invasion, meanwhile, lacking of significant breakthroughs in the diagnosis and treatment. The poor prognosis is attributed to many factors, of which the key ones are the late stage when patients are diagnosed, early invasion and metastasis, and resistance to chemotherapy and radiotherapy. Recently, more and more researches indicate that the abnormal expression of microRNA（miRNA） is associated with pancreatic cancer, miRNAs are a class of small non-coding RNAs involved in tumor initiation and development via degrading its mRNA or inhibiting its translation to regulate the expression of target gene. The latest studies suggest that the differential expression of miRNA in tumor tissues, blood circulation and other body fluids may contribute to the diagnosis of pancreatic cancer, and both of onco-miRNA and suppressor miRNA play an important role in the tumor proliferation, apoptosis and progression, being expected to be the new therapeutic targets of pancreatic cancer. Therefore, further researches on miRNAs related to diagnosis, treatment and prognosis of pancreatic cancer will give insight into its pathogenesis from a different side and open new avenues for anti-cancer strategies.

关 键 词：胰腺癌 微小RNA 诊断 治疗 预后 

分 类 号：R735.9[医药卫生—肿瘤]