基因测序技术在生殖领域的应用进展  

Application progress of gene sequencing technology in reproductive areas

作　　者：赵杰[1] 陈秀娟[1] 刘芳[1] 杜琛[1] 何江峰[2] 

机构地区：[1]内蒙古医科大学附属医院生殖医学中心,呼和浩特010050 [2]内蒙古农牧业科学院,呼和浩特010031

出　　处：《生殖与避孕》2016年第11期938-944,共7页Reproduction and Contraception

基　　金：内蒙古教育厅基金(NJZY16118);内蒙古医科大学科技百万工程项目(YKD2014KJBW007);内蒙古自然基金项目(2015BS0802)

摘　　要：基因测序技术自被发明以来在生命科学领域的研究中发挥着重要作用,利用测序技术对辅助生殖技术(ART)后代进行基因水平检测来评估ART的安全性,是一种非常有效的手段。而利用测序技术对植入前胚胎进行基因检测,不仅可以进行非整倍体筛查来选择优质胚胎进行移植,提高胚胎种植率,还可以避免遗传性疾病在家系内的传递;另外,利用测序技术对不孕不育患者进行基因方面检测,从而发现一些高敏感的致病基因,对于了解不孕不育疾病机理、发现治疗方案提供新的思路。Gene sequencing technology plays an important role in the research field of life science since it has been invented. Gene sequencing technology is effectively used to evaluate the safety of assisted reproductive technology （ART） by testing offspring through ART in gene level. Sequencing technologies can be used to test preimplantation embryos, it not only can increase the implantation rate of embryos by making aneuploidy screening to select high-quality embryos and transplantation, but also can avoid the hereditary disease passing in family. In addition, testing infertile patients in gene level by sequencing technology can discover some high-sensitive disease-causing genes, ultimately, it is useful to understand the mechanism of infertility disease and decide the treatment plan.

关 键 词：基因测序 辅助生殖技术(ART) 胚胎植入前遗传学诊断(PGD) 不孕不育 

分 类 号：R714.8[医药卫生—妇产科学] R440[医药卫生—临床医学]