己酮可可碱对慢性脑缺血患者认知功能影响的研究  

Effect of pentoxifylline on cognitive function in patients with chronic cerebral hypoperfusion： a prospective randomized controlled trial

作　　者：陈静[1] 章军建[1,2] 高永哲[1] 

机构地区：[1]武汉大学中南医院神经内科,430071 [2]湖北省痴呆与认知障碍医学临床研究中心

出　　处：《临床内科杂志》2016年第11期737-739,共3页Journal of Clinical Internal Medicine

基　　金：国家自然科学基金资助项目（30970962）

摘　　要：目的评价单效血液流变学活化剂己酮可可碱对慢性脑缺血患者脑血流量和认知功能的影响。方法67例慢性脑缺血患者分为药物试验组（32例，服用己酮可可碱12周）和病例对照组（35例，不服用己酮可可碱），采用动脉自旋标记灌注成像、简易精神状态量表（MMSE）和蒙特利尔认知评估量表（MoCA）分别测量药物试验组、病例对照组及正常对照组（30例）基线和12周后的局部脑血流（rCBF）和认知功能。结果药物试验组和病例对照组患者的rCBF和MoCA基线值较正常对照组均下降（P〈0．05），但3组MMSE基线值之间的差异无统计学意义（P〉0．05）。12周后药物试验组患者rCBF和MoCA评分较病例对照组升高，但仍低于正常对照组（P均〈0．05）。结论慢性脑缺血在患者的认知功能损害中发挥重要作用，己酮可可碱可通过提高脑血流量有效地改善其认知功能。Objective To evaluate the effect of the single-action hemorheological agent pentoxifylline on cerebral blood flow（CBF） and cognitive function in patients with chronic cerebral hypoperfusion（CCH）. Methods Regional cerebral blood flow（rCBF） and cognitive function were measured in drug test group （ CCH with daily oral pentoxifylline, n = 32 ） , case control group （ CCH without drug, n = 35 ） and normal control group （ n = 30 ） by arterial spin-labeling perfusion weighted imaging, the Mini Mental State Examination（MMSE） and Montreal Cognitive Assessment（MoCA） at baseline and after 12 weeks treatment. Results At baseline, rCBF and MoCA scores in patients of drug test group and case control group were lower than those in the normal control group （ P 〈 0.05 ） , while there was no statistical significance in MMSE scores（P 〉0.05）. Compared with case control group, rCBF and MoCA scores were increased in drug test group（P 〈 0.05）, but still lower than those in normal control group. Conclusion CBF plays an important part in the occurrence of cognitive impairment in patients with CCH. Pentoxifylline may effectively treat cognitive impairment by improving CBF in CCH patients.

关 键 词：慢性脑缺血 己酮可可碱 局部脑血流量 认知功能 

分 类 号：R749.16[医药卫生—神经病学与精神病学]