诱导多能干细胞-iPSCs在胆管病研究中的应用  

Application of induced pluripotent stem cells in cholangiopathies

作　　者：孙艳[1] 迟宝荣[2] 

机构地区：[1]吉林大学第二医院肿瘤血液内科,吉林省长春市130041 [2]吉林大学第一医院消化内科,吉林省长春市130021

出　　处：《世界华人消化杂志》2016年第31期4247-4252,共6页World Chinese Journal of Digestology

基　　金：吉林省国际科技合作基金资助项目;No.2016 0414037GH~~

摘　　要：诱导多能干细胞(induced pluripotent stem cells,i PSCs)是在形态、基因表达、细胞自我更新、以及分化潜能等方面与胚胎干细胞(embryonic stem cells,ESCs)相似的一类细胞,但却避免了ESCs应用中的免疫排斥和伦理道德等问题.i PSCs在多种疾病研究上取得的成就为肝脏疾病提供了良好的借鉴.以原发性胆汁性肝硬化、原发性硬化性胆管炎等为代表的一组胆管病虽非常见疾病,但发病机制不清、有效治疗手段匮乏、预后差.因此发展胆管病患者源性的、个体化的i PSCs及其诱导分化的功能细胞可在体外模拟疾病的表型及病理过程,应用此细胞模型对研究发病机制、药物筛选和疗效评估等具有重要意义.Induced pluripotent stem cells（i PSCs） are similar to embryonic stem cells（ESCs） in morphology, gene expression, cell self-renewal and differentiation potential. They avoid the problem of immune rejection and ethical issues associated with the application of ESCs. The application of i PSCs in a variety of diseases provides favorable experiences to the research of liver diseases. Cholangiopathies,such as primary biliary cirrhosis and primary sclerosing cholangitis, refer to a category of uncommon diseases that possess unclear pathogenesis, lack effective treatment and have a poor prognosis. Hence, investigating cholangiopathies-derived, individualized i PSCs and their differentiation into functional cells can mimic the disease phenotype and pathological process in vitro. The application of these cells has great significance for pathogenesis exploration, drug screening and therapeutic evaluation.

关 键 词：诱导多能干细胞 胆管病 胆管上皮细胞 

分 类 号：R575.6[医药卫生—消化系统]