钙卫蛋白在炎症性肠病诊断中临床价值的Meta分析  

Fecal calprotectin for diagnosis of infl ammatory bowel disease: A meta-analysis

作　　者：李林青[1] 曾俊[1] 王双[1] 陈欣[1] 姜政[1] 

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆市400016

出　　处：《世界华人消化杂志》2016年第31期4272-4278,共7页World Chinese Journal of Digestology

摘　　要：目的系统评价钙卫蛋白在炎症性肠病(inflammatory bowel disease,IBD)诊断中的临床价值.方法计算机检索Pub Med、EMBASE、中国期刊全文数据库、万方数字化期刊全文数据库,由两名人员独立查找评价应用钙卫蛋白在IBD诊断的文献,筛选符合纳入标准的文献,并对纳入文献进行质量评价.采用Meta-Disc1.40软件对数据进行统计学分析,计算汇总灵敏度、特异度、95%CI,并绘制SROC曲线,计算曲线下面积及Q*.结果共有13篇文献(共21组数据,其中I B D组7 2 1例,对照组6 6 4例)纳入研究,汇总灵敏度为0.86(95%CI:0.84-0.88),特异度为0.76(95%CI:0.74-0.79),SROC曲线下面积为0.9169,Q*为0.8498.结论钙卫蛋白对诊断IBD有较高的灵敏度、特异度,可用于临床辅助诊断IBD.AIM To evaluate the value of the fecal calprotectinin the diagnosis of infl ammatory bowel disease（IBD） patients systematically. METHODS PubMed,EMBASE,CNKI,and Wanfang digital journals database were searched for the studies which evaluated the value of the fecal calprotectin in the diagnosis of IBD patients. Meta-Disc 1.40 was used to calculate the pooled sensitivity specificity and 95% confidence intervals（95%CI）. The summary receiver operating characteristic curve（SROC） the area under the curve（AUC）,and Q＊ were also calculated.RESULTS A total of 13 studies involving 721 IBD patients and 664 controls were fi nally included in this meta-analysis. The pooled sensitivity and specifi city were 0.86（95%CI： 0.84-0.88） and 0.76（95%CI： 0.74-0.79） respectively. The AUC was 0.9169 and the Q＊ was 0.8498.CONCLUSION Fecal calprotectin is a good noninvasive marker with high sensitivity and specifi city in the diagnosis of IBD patients.

关 键 词：炎症性肠病 钙卫蛋白 META分析 

分 类 号：R574[医药卫生—消化系统]