老年无症状性脑梗死患者颈动脉粥样硬化以及血清微量元素水平的改变  

Changes of Carotid Atherosclerosis and Serum Trace Element Levels in Elderly Patients with Asymptomatic Cerebral Infarction

作　　者：张津津[1] 刘润梅[1] 李良[1] 翟红霞[1] 陈海威[1] 李娜[1] 王磊[1] 夏云峰[1] 

机构地区：[1]解放军总医院第一附属医院干一科,北京100048

出　　处：《现代生物医学进展》2016年第34期6656-6659,共4页Progress in Modern Biomedicine

基　　金：全军后勤科研计划面上项目(CWS14J070)

摘　　要：目的:研究老年无症状性脑梗死患者颈动脉粥样硬化以及血清微量元素水平的改变情况。方法:选取2014年1月至2015年6月在我院体检的无症状脑梗死患者78例为观察组和健康人群78例为对照组,分析两组患者的血清中微量元素、同型半胱氨酸水平(Hcy)和颈动脉粥样硬化状况。结果:经过超声检验发现,观察组患者中发现颈动脉粥样斑块的患者41例,无斑块患者37例,对照组人群78例中发现斑块的患者为21例,无斑块患者57例。根据检测结果显示,观察组的Hcy含量高于对照组,血清中的微量元素含量Zn^(2+),Mg^(2+),Cu^(2+),Pb^(2+)的含量观察组显著低于对照组,Ca^(2+),Fe^(2+),Cr^(2+)含量显著高于对照组。差异具有显著性(P<0.05)。结论:人体内锌、铜、铅、镁这几种微量元素的含量与颈动脉粥样硬化与老年无症状性脑梗死的发生率呈负相关,血清内同型半胱氨酸水平(Hcy)的含量、铁、钙、铬元素的含量与颈动脉粥样硬化与老年无症状性脑梗死发生率呈正相关。Objective： To study the changes of carotid atherosclerosis and serum trace element levels in elderly patients with asymptomatic cerebral infarction. Methods： 78 patients with asymptomatic cerebral infarction who underwent physical examination in our hospital from Jan 2014 to Jun 2015 were selected as observation group, and 78 healthy ones were chosen as control group. Serum trace elements level, serum homocysteine （Hey） level and carotid atherosclerosis situation of the two groups were analyzed. Results： The ultrasonic examination found that 41 patients in the observation group had carotid atherosclerotic plaques and 37 had not. The number in control group was 21 and 57, respectively. The test results showed that Hcy level in observation group was higher that of control group. As for trace elements level, the serum level of Zn2＋, Mg2＋, Cu2＋ and Pb2＋ in observation group were clearly lower than control group, while levels of Ca2＋, Fe2＋ and Cr2＋ were significantly higher. The differences were statistically significant （P〈0.05）. Conclusion： Levels of trace elements such as Zn, Cu, Pb and Mg in human body were negatively correlated to carotid atherosclerosis and occurrence rate of asymptomatic cerebral infarction in elderly patients, while serum levels of Hcy and Ca, Fe and Cr were positively correlated with carotid atherosclerosis and occurrence rate of asymptomatic cerebral infarction in elderly patients.

关 键 词：老年无症状性脑梗死 颈动脉粥样硬化 血清微量元素 

分 类 号：R743[医药卫生—神经病学与精神病学]