伊立替康联合卡铂辅助化疗对宫颈癌患者血清叶酸和CA125水平的影响  

Effect of Irinotecan and Carboplatin Chemotherapy on the Serum Folicacid,CA125 and Clinical Curative Effect of Cervical Cancer Patients

作　　者：李倩[1] 刘巧玲[2] 武渊[1] 朱必清[1] 陆谔梅[1] 陈静[1] 蒋明华[1] 

机构地区：[1]南京医科大学附属江苏省肿瘤医院放疗科,江苏南京210009 [2]南京市江宁医院妇产科,江苏南京211100

出　　处：《现代生物医学进展》2016年第33期6481-6483,6536,共4页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK2007553)

摘　　要：目的:探究伊立替康联合卡铂辅助化疗对宫颈癌患者血清叶酸、CA125及临床疗效的影响。方法:选择我院收治的宫颈癌患者41例,随机分成实验组和对照组。对照组19例予广泛全子宫切除及盆腔淋巴结清扫术;实验组22例在行全子宫切除及盆腔淋巴结清扫术前予卡铂和伊立替康治疗。对比两组的临床疗效以及治疗前后患者血清叶酸及CA125水平的变化。结果:实验组患者的有效率(81.8%)高于对照组(47.4%),其差异有统计学意义(P<0.05);治疗后,两组患者的血清CA125水平均降低、叶酸水平均升高(P<0.05),其差异有统计学意义;与对照组相比,实验组叶酸水平较高、血清CA125水平较低(P<0.05),差异有统计学意义。结论:伊立替康联合卡铂辅助化疗对宫颈癌患者有较好的临床疗效,推测其机制可能与降低患者CA125水平及提高叶酸水平有关。Objective： To investigate the effect of irinotecan plus carboplatin chemotherapy on the serum folic acid,CA125 and clinical curative effect of patients with cervical cancer. Method： 41 cases of cervical cancer patients from our hospital were selected and randomly divided into the control group and the experimental group. 19 cases in the control group were treated by extensive hysterectomy and pelvic lymph node dissection. 22 cases in the experiment group were treated by carboplatin and irinotecan. The clinical curative effect,serum folic acid and CA125 levels were detected and compared between two groups. Results： The effective rate of experimental group（81.8%） was higher than that of the control group（47.4%）（P〈0.05）. Compared with before treated, the serum CA125 level was lower and the serum folic acid was higher in both groups after treatment（P〈0.05）. Compared with the control group, the serum folic acid was higher and the serum CA125 was lower in the experiment group（P〈0.05）. Conclusion： Irinotecan combined with carboplatin chemotherapy had good clinical efficacy in the treatment of cervical cancer, which might be related to the decrease of serum CA125 level and increase of serum folic acid level.

关 键 词：宫颈癌 伊立替康 卡铂 叶酸 CA125 

分 类 号：R737.33[医药卫生—肿瘤]