Corneal regeneration by utilizing collagen based materials  

作　　者：Xuan Zhao Wenjing Song Sa Liu Li Ren 

机构地区：[1]School of Materials Science and Engineering, South China University of Technology [2]National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology

出　　处：《Science China Chemistry》2016年第12期1548-1553,共6页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(51273072,51232002);the Guangzhou Important Scientific and Technological Special Project(201508020123);the National Basic Research Program of China(2012CB619100);the Guangdong Scientific and Technological Project(2014B090907004)

摘　　要：Corneal disease is the main cause of blindness and keratoplasty is the only widely accepted treatment. Shortage of donor tissue makes the biomaterials for corneal regeneration a hot area of research. Collagen is the main component of corneal stroma, so collagen becomes a promising material for corneal repair. However, due to the drawbacks of collagen, it needs to be further modified to satisfy the requirement of corneal regeneration. In this article, we highlight the importance of collagen materials for corneal repair, and summarize several methods of preparing collagen based corneal regeneration materials, including chemical crosslinking, plastic compression of collagen, and collagen vitrigel. These modification methods can make collagen membranes with remarkable properties such as enough mechanical and suture retention strength, antibacterial property and excellent optical property. These materials may provide potential treatment for corneal disease.Corneal disease is the main cause of blindness and keratoplasty is the only widely accepted treatment. Shortage of donor tissue makes the biomaterials for corneal regeneration a hot area of research. Collagen is the main component of corneal stroma, so collagen becomes a promising material for corneal repair. However, due to the drawbacks of collagen, it needs to be further modified to satisfy the requirement of corneal regeneration. In this article, we highlight the importance of collagen materials for corneal repair, and summarize several methods of preparing collagen based corneal regeneration materials, including chemical crosslinking, plastic compression of collagen, and collagen vitrigel. These modification methods can make collagen membranes with remarkable properties such as enough mechanical and suture retention strength, antibacterial property and excellent optical property. These materials may provide potential treatment for corneal disease.

关 键 词：cornea regeneration COLLAGEN tissue engineering biomaterial 

分 类 号：R772.2[医药卫生—眼科]