Modification of polyfluorene nanoparticles via inclusion complexa- tion based on cyclodextrin for lectin sensing and cell imaging  

作　　者：PengfeiSun Mingchang Lin Guosong Chen Ming Jiang 

机构地区：[1]Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),Nanjing University of Posts&Telecommunications,Nanjing 210023,China [2]State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Fudan University,Shanghai 200433,China

出　　处：《Science China Chemistry》2016年第12期1616-1620,共5页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21474020,91227203,51322306 and91527305);the State Key Laboratory of Molecular Engineering of Polymers Program(K2016-17);the Innovation Program of the Shanghai Municipal Education Commission

摘　　要：Currently, conjugated polymer nanoparticles are widely used with many biological applications, especially bio-imaging and labeling. Thus their modification with different biomacromolecules becomes a crucial step before various applications. In literature,this modification was normally performed via covalent bonds. To our best knowledge, modification based on inclusion complexation has not been reported. Herein, via host-guest interaction between cyclodextrin and adamantane, supramolecular modification to conjugated polyfluorene nanoparticles has been successfully achieved. The glycopolymer-modified conjugated polymer nanoparticles showed excellent binding ability to lectins, such as Galectin-3 and selective imaging behavior to Hep G2 cells.Currently, conjugated polymer nanoparticles are widely used with many biological applications, especially bio-imaging and labeling. Thus their modification with different biomacromolecules becomes a crucial step before various applications. In liter- ature, this modification was normally performed via covalent bonds. To our best knowledge, modification based on inclusion complexation has not been reported. Herein, via host-guest interaction between cyclodextrin and adamantane, supramolecular modification to conjugated polyfluorene nanoparticles has been successfully achieved. The glycopolymer-modified conjugated polymer nanoparticles showed excellent binding ability to lectins, such as Galectin-3 and selective imaging behavior to Hep G2 cells.

关 键 词：inclusion complexation conjugated polymer nanoparticles POLYFLUORENE GLYCOPOLYMER Galectin-3 

分 类 号：O631[理学—高分子化学] TB383.1[理学—化学]