GLYCOPOLYMER

作品数:12被引量:8H指数:1
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相关领域:理学更多>>
相关期刊:《Chinese Journal of Chemical Engineering》《Science China Chemistry》《Chinese Journal of Polymer Science》《Journal of Donghua University(English Edition)》更多>>
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Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation
《Chinese Journal of Polymer Science》2024年第11期1661-1667,I0007,共8页Zhi Zhang Ce-Ce Xue Ying-Le Feng Guo-Song Chen 
supported by the National Key Research and Development Program of China(No.2023YFA0915300);the National Natural Science Foundation of China(Nos.52125303 and 92356305);Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD02)。
Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TAC...
关键词:Globo-H Mannobiose GLYCOPOLYMER Convergent Synthesis Tumor-associated carbohydrate antigens 
Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy被引量:1
《Acta Pharmaceutica Sinica B》2024年第5期2194-2209,共16页Zhilin Li Qianfeng Zhang Zhiqian Li Long Ren Dayi Pan Qiyong Gong Zhongwei Gu Hao Cai Kui Luo 
This work was supported by National Natural Science Foundation of China(32271445,52073193,and 82202322);National Science and Technology Major Project of China(2023YFB3810004);1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21013,China);the Sichuan Science and Technology Program(2023NSFSC1592,China),the China Postdoctoral Science Foundation(2021M692255,China);the Post-Doctor Research Project,West China Hospital,Sichuan University(2020HXBH094,China).
Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their application.To address this issue,we constructed a c...
关键词:GLYCOPOLYMER Polymer prodrug Immunogenic cell death Nanoassembly EPIRUBICIN STING pathway Immuno-supportive microenvironment Immunotherapy 
Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization
《Chinese Chemical Letters》2022年第9期4331-4334,共4页Xingyu Heng Ruyan Feng Lijuan Zhu Liyin Yu Gaojian Chen Hong Chen 
supported by the National Natural Science Foundation of China (Nos. 21935008 and 21774084);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and immunotherapy.Lipopolysaccharides(LPS)can promote DCs maturation by binding receptor on ...
关键词:LPS analogues GLYCOPOLYMER RAFT polymerization Dendritic cells(DCs) Immune enhancement 
Glycopolymer N-halamine-modified biochars with high specificity for Escherichia coli eradication
《Chinese Journal of Chemical Engineering》2021年第10期229-236,共8页Qinggele Borjihan Quanfu Yao Huihui Qu Haixia Wu Ying Liu Alideertu Dong 
supported by the National Natural Science Foundation of China(21304044,51663019,and 22062017);the Natural Science Foundation of Inner Mongolia Autonomous Region(2015MS0520,2019JQ03 and 2019BS02004);the State Key Laboratory of Medicinal Chemical Biology(201603006 and 2018051);the State Key Laboratory of Polymer Physics and Chemistry(2018-08);the Program of Higher-Level Talents of Inner Mongolia University(30105-125136)。
Antibiotic-resistant bacteria contamination in environments imposes great threats to human life health.This research aims to develop novel targeted antibacterial biochars for achieving high selectivity to kill pathoge...
关键词:Biochars N-HALAMINE GLYCOPOLYMER Antibacterial coating Specific killing 
Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment被引量:4
《Acta Pharmaceutica Sinica B》2021年第2期544-559,共16页Hao Cai Yufan Xiang Yujun Zeng Zhiqian Li Xiuli Zheng Qiang Luo Hongyan Zhu Qiyong Gong Zhongwei Gu Yanhui Liu Hu Zhang Kui Luo 
financially supported by the National Natural Science Foundation of China(Nos.51873120,51673127,and 81621003);Department of Science and Technology of Sichuan Province(Nos.2018JY0574,2017SZ0006,18GJHZ0139,and 2018HH0006,China);1·3·5 Research Funds in West China Hospital of Sichuan University(ZYGD18028,China)
Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer.Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs ...
关键词:STIMULI-RESPONSIVE Drug delivery Branched glycopolymers Biodegradability Nanomedicine THERANOSTICS 
Modification of polyfluorene nanoparticles via inclusion complexa- tion based on cyclodextrin for lectin sensing and cell imaging被引量:1
《Science China Chemistry》2016年第12期1616-1620,共5页PengfeiSun Mingchang Lin Guosong Chen Ming Jiang 
supported by the National Natural Science Foundation of China(21474020,91227203,51322306 and91527305);the State Key Laboratory of Molecular Engineering of Polymers Program(K2016-17);the Innovation Program of the Shanghai Municipal Education Commission
Currently, conjugated polymer nanoparticles are widely used with many biological applications, especially bio-imaging and labeling. Thus their modification with different biomacromolecules becomes a crucial step befor...
关键词:inclusion complexation conjugated polymer nanoparticles POLYFLUORENE GLYCOPOLYMER Galectin-3 
A facile approach to prepare hybrid nanoparticles with morphology controlled by the thickness of glyco-shell
《Chinese Chemical Letters》2015年第7期847-850,共4页Wei-Yi Zhang Guo-Song Chen 
Ministry of Science and Technology of China (No. 2011CB932503332);National Natural Science Foundation of China (No. 91227203, 21474020 and 51322306);the Shanghai Rising-Star Program (No. 13QA1400600) are acknowledged for their financial support
Herein, we designed a novel amphiphilic triblock glycopolymer poly(oligo(ethyleneglycol) methacry- late)-block-poly(maltopyranoside methacrylate)-block-polystyrene (POMA-b-PMal-b-PS) via the com- bination of r...
关键词:Glycopolymer Self-assembly Gold nanoparticles Morphology 
Synthesis of Thermoresponsive Poly( diethyleneglycol methacrylate-co-6-Ovinyladipoyl-D-glucopyranose) Glycopolymer via RAFT Polymerization
《Journal of Donghua University(English Edition)》2014年第4期515-519,共5页孙衎 徐慕儒 SYEDA Um-i-Zahra 聂华丽 权静 朱利民 
National Natural Science Foundation of China(No.21303014)
The monomer 6-O-vinyladipoyl-D-glucopyranose( VAG)was synthesized by lipase catalyzed trans-esterification of divinyladipate with D-glucopyranose. A novel double hydrophilic glycopolymer poly( diethyleneglycol methacr...
关键词:THERMORESPONSIVE GLYCOPOLYMER reversible additionfragmentation chain transfer(RAFT) polymerization NON-TOXIC 
Self-assembly and drug delivery behaviors of a novel thermo-sensitive block glycopolymer
《Chinese Science Bulletin》2010年第36期4187-4196,共10页CHEN LiQiong ZHANG LiMing CHEN JianJun YANG Jian LI RongXian 
supported by the National Natural Science Foundation of China (30470476, 20676155);Natural Science Foundation of Guang-dong Province, China (06023103)
A novel thermo-sensitive block glycopolymer based on peracetylated maltoheptaose (AcMH) and poly(2-ethyl-2-oxazoline) (PEtOz) was synthesized for the first time and characterized by hydrogen nuclear magnetic resonance...
关键词:自组装行为 药物输送 温敏 凝胶渗透色谱仪 透射电子显微镜 嵌段聚合物 胶束结构 核磁共振光谱 
Synthesis and self-assembly of amphiphilic ABA type triblock copolymer with well-defined glycopolymer segments被引量:1
《Chinese Science Bulletin》2008年第9期1343-1351,共9页WANG JianYu QIAN YanLing ZHANG Fan ZHU BaoKu XU YouYi 
Supported by the National Natural Science Foundation of China (Grant No. 50433010);the State Key Basic Research Program (973 Program) of China (Grant No. 2003CB615705)
A novel amphiphilic ABA type triblock copolymer with well-defined glycopolymer segments was suc- cessfully synthesized via the atom transfer radical polymerization (ATRP) technique, using a bromo-terminated difunction...
关键词:两性分子 共聚物 丙三醇 ATRP 
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