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supported by the National Key Research and Development Program of China(No.2023YFA0915300);the National Natural Science Foundation of China(Nos.52125303 and 92356305);Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD02)。
Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TAC...
This work was supported by National Natural Science Foundation of China(32271445,52073193,and 82202322);National Science and Technology Major Project of China(2023YFB3810004);1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21013,China);the Sichuan Science and Technology Program(2023NSFSC1592,China),the China Postdoctoral Science Foundation(2021M692255,China);the Post-Doctor Research Project,West China Hospital,Sichuan University(2020HXBH094,China).
Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their application.To address this issue,we constructed a c...
supported by the National Natural Science Foundation of China (Nos. 21935008 and 21774084);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and immunotherapy.Lipopolysaccharides(LPS)can promote DCs maturation by binding receptor on ...
supported by the National Natural Science Foundation of China(21304044,51663019,and 22062017);the Natural Science Foundation of Inner Mongolia Autonomous Region(2015MS0520,2019JQ03 and 2019BS02004);the State Key Laboratory of Medicinal Chemical Biology(201603006 and 2018051);the State Key Laboratory of Polymer Physics and Chemistry(2018-08);the Program of Higher-Level Talents of Inner Mongolia University(30105-125136)。
Antibiotic-resistant bacteria contamination in environments imposes great threats to human life health.This research aims to develop novel targeted antibacterial biochars for achieving high selectivity to kill pathoge...
financially supported by the National Natural Science Foundation of China(Nos.51873120,51673127,and 81621003);Department of Science and Technology of Sichuan Province(Nos.2018JY0574,2017SZ0006,18GJHZ0139,and 2018HH0006,China);1·3·5 Research Funds in West China Hospital of Sichuan University(ZYGD18028,China)
Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer.Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs ...
supported by the National Natural Science Foundation of China(21474020,91227203,51322306 and91527305);the State Key Laboratory of Molecular Engineering of Polymers Program(K2016-17);the Innovation Program of the Shanghai Municipal Education Commission
Currently, conjugated polymer nanoparticles are widely used with many biological applications, especially bio-imaging and labeling. Thus their modification with different biomacromolecules becomes a crucial step befor...
Ministry of Science and Technology of China (No. 2011CB932503332);National Natural Science Foundation of China (No. 91227203, 21474020 and 51322306);the Shanghai Rising-Star Program (No. 13QA1400600) are acknowledged for their financial support
Herein, we designed a novel amphiphilic triblock glycopolymer poly(oligo(ethyleneglycol) methacry- late)-block-poly(maltopyranoside methacrylate)-block-polystyrene (POMA-b-PMal-b-PS) via the com- bination of r...
National Natural Science Foundation of China(No.21303014)
The monomer 6-O-vinyladipoyl-D-glucopyranose( VAG)was synthesized by lipase catalyzed trans-esterification of divinyladipate with D-glucopyranose. A novel double hydrophilic glycopolymer poly( diethyleneglycol methacr...
supported by the National Natural Science Foundation of China (30470476, 20676155);Natural Science Foundation of Guang-dong Province, China (06023103)
A novel thermo-sensitive block glycopolymer based on peracetylated maltoheptaose (AcMH) and poly(2-ethyl-2-oxazoline) (PEtOz) was synthesized for the first time and characterized by hydrogen nuclear magnetic resonance...
Supported by the National Natural Science Foundation of China (Grant No. 50433010);the State Key Basic Research Program (973 Program) of China (Grant No. 2003CB615705)
A novel amphiphilic ABA type triblock copolymer with well-defined glycopolymer segments was suc- cessfully synthesized via the atom transfer radical polymerization (ATRP) technique, using a bromo-terminated difunction...