Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation  

作　　者：Zhi Zhang Ce-Ce Xue Ying-Le Feng Guo-Song Chen 

机构地区：[1]The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science,Fudan University,Shanghai,200433,China [2]School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an,710119,China

出　　处：《Chinese Journal of Polymer Science》2024年第11期1661-1667,I0007,共8页高分子科学（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2023YFA0915300);the National Natural Science Foundation of China(Nos.52125303 and 92356305);Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD02)。

摘　　要：Tumor-associated carbohydrate antigens(TACAs)provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy.However,the weak immunogenicity and structural complexity of TACAs are obstacles to their clinical application.Here,based on a fast and low-cost purification strategy for oligosaccharide synthesis,the synthesis of tumour-associated carbohydrate antigens Globo H and mannobiose which resembles repeat unit of mannan was achieved.To enhance the immunogenicity and multivalent effect,Globo H and mannobiose were covalently attached to degradable polymer backbones.2D spindle-like lamellar micelle and globular micelle were obtained from glycopolymer through a solvent-exchange method of self-assembly.The glyconanoparticle showed good biocompatibility and degradability.Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored.

关 键 词：Globo-H Mannobiose GLYCOPOLYMER Convergent Synthesis Tumor-associated carbohydrate antigens 

分 类 号：O629[理学—有机化学] R730.3[理学—化学]