Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization  

作　　者：Xingyu Heng Ruyan Feng Lijuan Zhu Liyin Yu Gaojian Chen Hong Chen 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China [2]Center for Soft Condensed Matter Physics and Interdisciplinary Research,Soochow University,Suzhou 215006,China

出　　处：《Chinese Chemical Letters》2022年第9期4331-4334,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 21935008 and 21774084);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

摘　　要：Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and immunotherapy.Lipopolysaccharides(LPS)can promote DCs maturation by binding receptor on DCs surface,but their clinical application is limited due to biological toxicity.Although many LPS analogues have been developed,complex synthesis and purification hinder their practical application.Here,we propose a novel and simple strategy to synthesize LPS analogues with adjustable structural units.Using monomer units similar to the key functional groups of LPS,we synthesize LPS analogues with different group ratios by RAFT polymerization.The obtained analogues have little negative effect on cell viability.Compared with LPS,the analogues show greater promoting effect on DCs maturation.And the analogues can be applied to different scenarios since the degrees of promoting DCs maturation by LPS analogues with different group ratios are different.This strategy provides a new direction for synthesizing LPS analogues,and it has the potential to produce LPS analogues on a large scale with tunable promoting DCs maturation effect.

关 键 词：LPS analogues GLYCOPOLYMER RAFT polymerization Dendritic cells(DCs) Immune enhancement 

分 类 号：R392[医药卫生—免疫学]