肺外小细胞癌的临床病理特征及综合治疗策略  

Retrospective Review of Extra-pulmonary Small Cell Carcinoma and Therapeutic Methods

作　　者：戴永美[1] 徐驯宇[2] 黄郴[2] 崔同建[1] 

机构地区：[1]福建医科大学省立临床学院福建省立医院肿瘤内科,福建福州350122 [2]福建医科大学省立临床学院福建省立医院胸外科,福建福州350122

出　　处：《中外医疗》2016年第31期37-39,共3页China & Foreign Medical Treatment

基　　金：福建省科技厅引导项目(2015Y0004)

摘　　要：目的分析肺外小细胞癌(extrapulmonary small cell carcinoma,EPSCC)的临床病理特征及不同治疗模式对预后的影响。方法方便选取并回顾性分析2012年8月—2015年12月福建省立医院收治20例肺外小细胞癌患者的临床病理特征及治疗方法、预后分析。结果共20例EPSCC,男15例,女5例,平均年龄61.1岁。I期2例,II期4例;III期10例;IV期4例;原发灶位置:食管12例,纵膈2例,胃食管交界处、闭孔、输尿管、子宫、卵巢各1例,原发病灶不明1例。采用化疗或手术的患者中位OS均为6个月,均无2年以上生存的病例,采用综合治疗的患者中位OS 15.2个月,1年生存率50%,2年生存率12.5%年以上,对症支持治疗的患者中位OS 2.1个月。结论肺外小细胞癌发病率低,目前尚无标准的治疗方法,采用综合治疗模式优于单一治疗方式。Objective Extra-pulmonary small cell carcinoma（EPSCC） is a rare cause of malignancy. The purpose of this study is to clinicopathological characteristics of patients with EPSCC, and to analyze different therapeutic methods. Methods Convenient selection and retrospective review of all patients with EPSCC between August 2012 and December 2015 was conducted.Patients included for analysis had pathologic diagnosis of EPSCC, poorly differentiated tumors, and negative chest imaging at diagnosis. Results 20 patients were included in the analysis. Male 15 patients,female 15 patients;The primary disease sites were： carcinoma of unknown primary 1 patients, esophagus 12 patients, mediastina 2 patients,and gastroesophageal junction, obturator, ureters, uterus and ovary 1 patients, respectly;Overall survival：The median overall survival（OS） was 6 months for surgery or chemotherapy, 12.5 months for integrated therapy,2.1 months for support therapy. Conclusion EPSCC is a rare cause of malignancy., there is no standard treatment method, the comprehensive treatment mode is better than the single treatment.

关 键 词：肺外小细胞癌 临床病理特征 治疗策略 

分 类 号：R730[医药卫生—肿瘤]