KIR的分子遗传多态性及测序分型技术的研究进展  

Progress in research on genetic polymorphisms and sequence-based typing of KIR genes

作　　者：甄建新[1] 喻琼[1] 

机构地区：[1]广东省深圳市血液中心,518035

出　　处：《中华医学遗传学杂志》2016年第6期867-870,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金（81373158）

摘　　要：杀伤细胞免疫球蛋白样受体（killer cell immunoglobulin-like receptor, KIR）为免疫球蛋白超家族成员，主要表达于自然杀伤细胞（natural killer，NK）和某些T细胞亚群。KIR主要与人类白细胞抗原（human leukocyte antigen, HLA）I类分子配位，组成KIRHLA受配体复合物，传导激活或抑制信号，调节NK细胞活性，在移植免疫、肿瘤免疫、抗感染免疫以及自身免疫性疾病等生理病理过程中起重要作用。本文阐述了KIR分子遗传多态性，总结了当前国际KIR测序分型方法的特点及急待解决的问题。Killer cell immunoglobulin-like receptors （KIRs） are members of the immunoglobulin superfamily expressed on natural killer （NK） cells and a subset of T ceils. Given the receptor-ligand relationship between certain KIR and human leukocyte antigen （HLA） class I molecules, the KIRs are involved in the regulation of NK cell activation through conveying activating or inhibitory signals, which plays an important role in immunities involved in transplantation, tumor, infection as well as autoimmune diseases. This paper has provided a review for the research on KIR gene polymorphisms and summarized the characteristics of the sequence-based typing method for KIR genes.

关 键 词：自然杀伤细胞 杀伤细胞免疫球蛋白样受体 遗传多态性 测序分型 

分 类 号：R3[医药卫生—基础医学]