基于病证结合肠易激综合征动物模型构建方法及研究思路  

Progress and ideas of irritable bowel syndrome animal model construction based on combination of disease and syndrome

作　　者：旺建伟[1,2] 张秋樾 胥风华[4] 叶虹玉 赵文静[1,2] WANG Jian-wei ZHANG Qiu-yue XU Feng-hua YE Hong-yu ZHAO Wen-jing(Basic Medicine College of Heilongfiang University of Chinese Medicine Heilongjiang Key Laboratory of Basic of TCM Pharmacy College of Heilong]iang University of Chinese Medicine the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin Heilongjiang 150040, China)

机构地区：[1]黑龙江中医药大学基础医学院中药学教研室 [2]黑龙江省中医药基础重点实验室 [3]黑龙江中医药大学药学院 [4]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中国药理学通报》2016年第9期1198-1202,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上项目(No 81573870);中国博士后科学基金第8批特别资助项目(No 2015T80376);中国博士后科学基金项目(No 2013M531079);黑龙江省博士后资助项目(No LBH-Z12246);黑龙江省自然科学基金(面上项目)(No H2015020);黑龙江中医药大学优秀创新人才支持计划资助(优秀青年学术带头人)(No 051217)

摘　　要：构建病证结合动物模型是进行中医药研究比较理想的技术平台。目前,诸多学者在现代医学疾病动物模型基础上结合病因制作病证动物模型,制备了适宜的相应的肠易激综合征病证结合模型,体现中医对肠易激综合征辩证优势,促进了病证结合动物模型研究的发展,但仍存在着对证候评价主观性、重病轻证等问题。因此在病证结合模型复制、筛选、评价方面,在不断深入疾病发病机制及中医证候研究基础上,通过方证相关结合系统生物学研究方法,进行深入中医证候内涵相关研究,改进病证模型的研究、构建方法,病证结合动物模型制备思路更成熟,以阐明中医药的科学内涵。Establishment of combination of disease and syndrome animal model is an ideal technology platform in TCM research.Currently,many scholars have prepared matching IBS animal models combined typical animal models with etiology,which embodies the advantages of syndrome differentiation and promotes the development of combination disease and syndrome animal model. Even though,there still exists some problems about subjective evaluation on syndromes,paying more attention on disease and less on syndromes. Therefore,we should deepen the pathogenesis of diseases and TCM syndromes research on animal model replication and improve the method of construction of combination of disease and syndrome animal model through the biological research of combination of disease and syndrome system. By this way,the idea of preparation animal models will be more mature and the scientific connotation of TCM will be presented more exactly.

关 键 词：肠易激综合征 病证结合 动物模型 方证相关 系统生物学 研究思路 

分 类 号：R332[医药卫生—人体生理学] R256.3[医药卫生—基础医学]