吲哚菁绿与纳米碳在乳腺癌前哨淋巴结活检中的对比研究  

Comparison of indocyanine green and carbon nanoparticles for detection of sentinel lymph nodes in breast cancer

作　　者：邹伟伟[1] 白玉[1] 王希龙[1] 程凯[1] 孙洪光[1] 武孟孟[1] 李高峰[1] 杨振林[1] 

机构地区：[1]滨州医学院附属医院甲状腺乳腺外科,山东滨州256603

出　　处：《中国普通外科杂志》2016年第11期1627-1632,共6页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81173601);滨州医学院科技计划资助项目(BY2013KJ06);滨州医学院科研计划与科研启动基金资助项目(BY2015KJ23)

摘　　要：目的:比较吲哚菁绿(ICG)、纳米碳混悬注射液在乳腺癌前哨淋巴结(SLN)示踪中的应用效果。方法:选择2013年11月—2016年7月收治乳腺癌行前哨淋巴结活检(SLNB)的患者136例,其中以ICG为示踪剂者60例(ICG组),以纳米碳混悬注射液为示踪剂者76例(纳米碳组)。比较两组的相关指标。结果:两组基本临床资料差异无统计学意义(均P>0.05);ICG组与纳米碳组SLN的检出率(96.67%vs.100%)、灵敏度(89.47%vs.95.83%)、假阴性率(10.53%vs.4.17%)、准确率(93.33%vs.98.68%),组间差异均无统计学意义(均P>0.05);ICG组较纳米碳组SLN检出数目少(3.17枚vs.3.92枚,P=0.000),但检出时间短(25.72 min vs.49.29 min,P=0.000);年龄、体质量指数(BMI)并不影响两种方法的SLN检出率及SLNB准确率(均P>0.05)。结论:ICG与纳米碳混悬注射液示踪乳腺癌SLN具有相似的效能,并且均操作简便,便于推广实施。Objective： To compare the efficacy of indocyanine green （IGG） with that of carbon nanoparticles suspension injection for detection of sentinel lymph nodes （SLNs） in breast cancer.Methods： One-hundred and thirty-six patients with early breast cancer undergoing sentinel lymph node biopsy （SLNB） from November 2013 to July 2016 were enrolled. Of the patients, IGG was used as a tracer in 60 cases （IGG group） and carbon nanoparticles suspension injection was used in the other 76 cases （nano-carbon group）. The relevant variables between the two groups were compared.Results： The general clinical data showed no statistical di？erence between the two group of patients （all P〉0.05）. Between IGG group and nano-carbon group, all the parameters that included the detection rate of the SLNs （96.67% vs. 100%）, sensitivity （89.47% vs. 95.83%）, accuracy （93.33% vs. 98.68%） and false negative rate （10.53% vs. 4.17%） had no statistical difference （all P〉0.05）. The number of detected SLNs in ICG group was less than that in nano-carbon group （3.17 vs. 3.92, P=0.000）, but the time for detection in IGG group was significantly shorter than that in nano-carbon group （25.72 min vs. 49.29 min, P=0.000）. Age and body mass index （BMI） did not affect the detection rate of SLNs and accuracy of SLNB of the two methods （all P〉0.05）.Conclusion： IGG and carbon nanoparticles suspension injection have similar efficiency for detection of SLNs in breast cancer, and both are easy and convenient to use.

关 键 词：乳腺肿瘤 前哨淋巴结活组织检查 吲哚花青绿 纳米粒子 碳 

分 类 号：R737.9[医药卫生—肿瘤]